Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 51: 891-897, 2005. First published March 17, 2005; 10.1373/clinchem.2004.044453
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
clinchem.2004.044453v1
51/5/891    most recent
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Herrmann, W.
Right arrow Articles by Kuhlmann, M. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Herrmann, W.
Right arrow Articles by Kuhlmann, M. K.
Related Collections
Right arrow General Clinical Chemistry
Right arrow Lipids, Lipoproteins, and Cardiovascular Risk Factors
(Clinical Chemistry. 2005;51:891-897.)
© 2005 American Association for Clinical Chemistry, Inc.

General Clinical Chemistry

Disturbed Homocysteine and Methionine Cycle Intermediates S-Adenosylhomocysteine and S-Adenosylmethionine Are Related to Degree of Renal Insufficiency in Type 2 Diabetes

Wolfgang Herrmann1,a, Heike Schorr1, Rima Obeid1, Julia Makowski2, Brian Fowler3 and Martin K. Kuhlmann2,4

1 Department of Clinical Chemistry, Central Laboratory, and 2 Department of Nephrology and Hypertension, Saarland University Hospital, Homburg, Germany.
3 Metabolic Unit, University Children’s Hospital, Basel, Switzerland.
4 Renal Research Institute, New York, NY.

aAddress correspondence to this author at: Zentrallabor der Universitätskliniken des Saarlandes, Gebäude 57, 66421 Homburg, Germany. Fax 49-6841-1630703; e-mail kchwher{at}uniklinik-saarland.de.

Background: Diabetic nephropathy is a common complication in patients with type 2 diabetes that may increase atherothrombotic risk. Hyperhomocysteinemia (HHcy) further increases the risk in those patients. We studied concentrations of total homocysteine (tHcy) and its related metabolites S-adenosylmethionine (AdoMet) and S-adenosylhomocysteine (AdoHcy) in relation to B-vitamin status and renal function in patients with type 2 diabetes who developed diabetic nephropathy.

Methods: The study included 93 patients with renal failure and type 2 diabetes. Chronic kidney disease was classified into four subgroups according to the National Kidney Foundation based on glomerular filtration rate plus pathologic abnormalities or markers of kidney damage.

Results: Serum or plasma concentrations of the metabolites increased significantly with worsening of renal function, whereas serum concentrations of the B vitamins (folate, vitamins B12 and B6) did not differ appreciably between the groups. Moreover, plasma concentrations of AdoHcy and AdoMet were markedly increased in patients with kidney failure compared with those in stage 2 (median AdoHcy, 112.7 vs 10.5 nmol/L; median AdoMet, 162.0 vs 80.0 nmol/L). The AdoMet/AdoHcy ratio was more than 80% lower in patients with renal failure compared with stage 2. Vitamin B12 was a significant determinant of concentrations of AdoMet, tHcy, methylmalonic acid (MMA), and cystathionine.

Conclusions: Increased plasma concentrations of tHcy and methionine cycle intermediates (AdoMet, AdoHcy) are related to disturbed renal function in patients with type 2 diabetes. Vitamin B12 and/or folate are significant predictors of tHcy, cystathionine, MMA, and AdoMet. The effect of therapeutic doses of the B vitamins on AdoMet, AdoHcy, and their ratio should be tested in renal patients.




The following articles in journals at HighWire Press have cited this article:


Home page
 J EndocrinolHome page
M. Y. Ali, M. Whiteman, C.-M. Low, and P. K Moore
Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway
J. Endocrinol., October 1, 2007; 195(1): 105 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. P Stabler, R. H Allen, E. T Dolce, and M. A. Johnson
Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment
Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1422 - 1429.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
Y. Kaneko, Y. Kimura, H. Kimura, and I. Niki
L-Cysteine Inhibits Insulin Release From the Pancreatic {beta}-Cell: Possible Involvement of Metabolic Production of Hydrogen Sulfide, a Novel Gasotransmitter.
Diabetes, May 1, 2006; 55(5): 1391 - 1397.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the American Association for Clinical Chemistry.