HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: clinchem.2004.044859v1 51/8/1451    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Yu, X. Articles by Fornage, M. Search for Related Content PubMed PubMed Citation Articles by Yu, X. Articles by Fornage, M. Related Collections Molecular Diagnostics and Genetics Lipids, Lipoproteins, and Cardiovascular Risk Factors Endocrinology and Metabolism

The Uncoupling Protein 2 Ala55Val Polymorphism Is Associated with Diabetes Mellitus: The CARDIA Study

¹ Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN.
² Department of Nutrition, University of Oslo, Oslo, Norway.
³ Department of Laboratory Medicine, Medical School, University of Minnesota, Minneapolis, MN.
⁴ Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX.

^aAddress correspondence to this author at: University of Minnesota, Division of Epidemiology, School of Public Health, 1300 South 2nd St., Suite 300, Minneapolis, MN 55454. Fax 612-624-0315; e-mail jacobs{at}epi.umn.edu.

Background: Uncoupling proteins (UCPs) reduce ATP generation with concomitant increased release of heat. The activities of UCPs have been related to obesity and energy metabolism.

Methods: We investigated the association of the commonly observed UCP2 Ala55Val (V) polymorphism with diabetes mellitus and impaired fasting glucose (IFG) among 3684 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Results: The V frequency was 45% in blacks and 42% in whites. Those with the Val/Val (VV) genotype had a higher incidence of diabetes than those having the Ala/Ala (AA) genotype (5.8% vs 3.3%; P = 0.02). Similarly, the incidences of diabetes in participants without abdominal obesity were 2.8% and 1.0% (P = 0.03) in the VV and AA groups, and 12.4% and 8.3% (P = 0.15) in participants with abdominal obesity. The incidence of IFG was higher in VV vs AA only in those without abdominal obesity (12.9% vs 9.2%). These trends persisted in minimally and fully adjusted models, and in strata of blacks and whites and men and women. The homeostasis model assessment for insulin resistance was highest in VV in the combined group of those with IFG or untreated diabetes, but not in those with normal fasting glucose.

Conclusion: The VV genotype of the UCP2 polymorphism was positively related to diabetes. It may involve increased insulin resistance in those with impaired glucose homeostasis.

The following articles in journals at HighWire Press have cited this article:

				T. E. Meyer, E. Boerwinkle, A. C. Morrison, K. A. Volcik, M. Sanderson, A. L. Coker, J. S. Pankow, and A. R. Folsom Diabetes Genes and Prostate Cancer in the Atherosclerosis Risk in Communities Study Cancer Epidemiol. Biomarkers Prev., February 1, 2010; 19(2): 558 - 565. [Abstract] [Full Text] [PDF]

				E. Chevillotte, M. Giralt, B. Miroux, D. Ricquier, and F. Villarroya Uncoupling Protein-2 Controls Adiponectin Gene Expression in Adipose Tissue Through the Modulation of Reactive Oxygen Species Production Diabetes, April 1, 2007; 56(4): 1042 - 1050. [Abstract] [Full Text] [PDF]