HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: clinchem.2005.051581v1 51/9/1661    most recent Submit an electronic Letter to the Editor about this paper Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Gulesserian, T. Articles by Huber, K. Search for Related Content PubMed PubMed Citation Articles by Gulesserian, T. Articles by Huber, K. Related Collections Molecular Diagnostics and Genetics Lipids, Lipoproteins, and Cardiovascular Risk Factors

Clinical Restenosis after Coronary Stent Implantation Is Associated with the Heme Oxygenase-1 Gene Promoter Polymorphism and the Heme Oxygenase-1 +99G/C Variant

¹ Clinical Institute of Medical and Chemical Laboratory Diagnostics, ² Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, and ³ Department of Cardiology, Medical University of Vienna, Vienna, Austria.
⁴ 3rd Department of Medicine (Cardiology and Emergency Medicine), Wilhelminenhospital, Vienna, Austria.

^aAddress correspondence to this author at: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Fax 43-1-40400-5389; e-mail Oswald.Wagner{at}meduniwien.ac.at.

Background: Vascular remodeling after percutaneous coronary stent implantation frequently leads to restenosis. Heme oxygenase 1 (HO-1) is involved in the generation of the endogenous antioxidant bilirubin and carbon monoxide, both of which exert antiinflammatory and antiproliferative effects. The aim of the present study was to evaluate the influence of genetic risk factors combined with the conventional risk factors on the development of coronary restenosis after percutaneous coronary intervention (PCI) with stent implantation.

Methods: The HO-1 gene GT dinucleotide repeat promoter polymorphism and HO-1 +99G/C variant were evaluated in 199 patients with coronary artery disease after coronary stent implantation and control angiography at 6 months after the intervention. Coronary restenosis was confirmed by quantitative angiography.

Results: Carriers of the long allele of the HO-1 gene promoter (>29 repeats) had a significantly higher risk of developing restenosis after PCI than noncarriers [odds ratio (OR) = 1.9; 95% confidence interval (95% CI), 1.0–3.4; P = 0.04]. Interestingly, the allele longer than 29 repeats conferred a significantly higher risk of developing restenosis (OR = 3.4; 95% CI, 1.2–9.1; P = 0.017) in nonsmokers than in smokers (OR = 2.0; 95% CI, 0.7–5.2; P = 0.18).

Conclusions: The long allele of the HO-1 gene promoter (>29 repeats) polymorphism, which leads to low HO-1 inducibility, may represent an independent prognostic marker for restenosis after PCI and stent implantation. The effect of the >29 repeat allele is attenuated in smokers, who have chronic exogenous CO exposure.

The following articles in journals at HighWire Press have cited this article:

				L. E. Fredenburgh, M. A. Perrella, and S. A. Mitsialis The Role of Heme Oxygenase-1 in Pulmonary Disease Am. J. Respir. Cell Mol. Biol., February 1, 2007; 36(2): 158 - 165. [Abstract] [Full Text] [PDF]

				T. W. Sedlak and S. H. Snyder Messenger Molecules and Cell Death: Therapeutic Implications JAMA, January 4, 2006; 295(1): 81 - 89. [Abstract] [Full Text] [PDF]