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Endocrinology and Metabolism |
1 Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
2 Laboratory of Nuclear Medicine, AHEPA University Hospital of Thessaloniki, Thessaloniki, Greece.
3 Endocrine Section of the First Department of Internal Medicine, Athens University School of Medicine, Athens, Greece.
aAddress correspondence to this author at: Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 119, Mitropoleos Str., 54622, Thessaloniki, Greece. Fax 30-2310-346942; e-mail argic{at}med.auth.gr.
Background: The present study was designed to investigate the effects of polycystic ovary syndrome (PCOS) and of obesity on serum parathyroid hormone (PTH), 25-hydroxyvitamin D (25-OH-vitamin D), and 1,25-dihydroxyvitamin D [1,25-(OH)2-vitamin D] concentrations and the possible associations of the above calciotropic hormones with the hormonal and metabolic characteristics of the syndrome.
Methods: We studied 58 obese [body mass index (BMI) >30 kg/m2] women with PCOS, 64 overweight (BMI, 25–30 kg/m2) women with the syndrome, 169 normal-weight (BMI <25 kg/m2) women with PCOS, 29 obese controls (ovulatory women without clinical or biochemical hyperandrogenemia), 14 overweight controls, and 70 normal-weight controls. Blood samples were collected (at 0900 after an overnight fast) between the 3rd and 6th days of a menstrual cycle in the control groups and during a spontaneous bleeding episode in the PCOS groups. Circulating concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), testosterone, 
4-androstenedione, 17
-hydroxyprogesterone, sex-hormone–binding globulin (SHBG), insulin, glucose, PTH, 25-OH-vitamin D, and 1,25-(OH)2-vitamin D were measured.
Results: Both PCOS and increased body weight had a significant positive effect on serum PTH values. PTH concentrations were significantly correlated with age, BMI, glucose, PRL, SHBG, and testosterone. Only the correlations with testosterone and PRL were BMI-independent. The effect of PCOS on PTH concentrations remained significant after adjustment for BMI, but not after adjustment for testosterone concentration. Increased body weight also had a significant negative effect on 25-OH- and 1,25-(OH)2-vitamin D concentrations, but no association with the syndrome was observed.
Conclusions: The results of the present study are in agreement with previous data supporting an association of increased PTH and decreased vitamin D metabolite concentrations with obesity. Moreover, the present findings indicate, for the first time, that PTH probably is also linked to PCOS-associated hyperandrogenism.
The following articles in journals at HighWire Press have cited this article:
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  E Wehr, S Pilz, N Schweighofer, A Giuliani, D Kopera, T R Pieber, and B Obermayer-Pietsch Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome Eur. J. Endocrinol., October 1, 2009; 161(4): 575 - 582. [Abstract] [Full Text] [PDF]
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 D. Farmakiotis, I. Katsikis, and D. Panidis Calcium homeostasis and anovulatory infertility Hum. Reprod., December 1, 2007; 22(12): 3264 - 3264. [Full Text] [PDF]
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T. Reinehr, G. de Sousa, U. Alexy, M Kersting, and W. Andler Vitamin D status and parathyroid hormone in obese children before and after weight loss Eur. J. Endocrinol., August 1, 2007; 157(2): 225 - 232. [Abstract] [Full Text] [PDF]
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 A. A. Sule and M. K. S. Leow Association of polycystic ovary syndrome and fibromyalgia in a patient with primary hyperparathyroidism: a novel triad? Clin. Chem., June 1, 2006; 52(6): 1208 - 1209. [Full Text] [PDF]
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A. Kourtis, D. Rousso, C. Balaris, D. Farmakiotis, I. Katsikis, and D. Panidis Association of polycystic ovary syndrome and fibromyalgia in a patient with primary hyperparathyroidism: a novel triad? - reply. Clin. Chem., June 1, 2006; 52(6): 1209 - 1210. [Full Text] [PDF]
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