Clinical Chemistry
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Clinical Chemistry 52: 37-45, 2006. First published November 18, 2005; 10.1373/clinchem.2005.059600
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(Clinical Chemistry. 2006;52:37-45.)
© 2006 American Association for Clinical Chemistry, Inc.

Review

Clinical Analysis by Microchip Capillary Electrophoresis

Sam F.Y. Li1,2,a and Larry J. Kricka1

1 Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA.
2 Department of Chemistry, National University of Singapore, Singapore, Republic of Singapore.

aAddress correspondence to this author at: Department of Pathology & Laboratory Medicine, 7.103 Founders Pavilion, University of Pennsylvania Medical Center, 3400 Spruce St., Philadelphia, PA 19104. Fax 215-662-7529; e-mail lisam{at}uphs.upenn.edu or chmlifys{at}nus.edu.sg.

Clinical analysis often requires rapid, automated, and high-throughput analytical systems. Microchip capillary electrophoresis (CE) has the potential to achieve very rapid analysis (typically seconds), easy integration of multiple analytical steps, and parallel operation. Although it is currently still in an early stage of development, there are already many reports in the literature describing the applications of microchip CE in clinical analysis. At the same time, more fully automated and higher throughput commercial instruments for microchip CE are becoming available and are expected to further enhance the development of applications of microchip CE in routine clinical testing. To put into perspective its potential, we briefly compare microchip CE with conventional CE and review developments in this technique that may be useful in diagnosis of major diseases.






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Copyright © 2006 by the American Association for Clinical Chemistry.