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This Article Full Text Full Text (PDF) All Versions of this Article: clinchem.2005.049452v1 52/1/97    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by González-Sánchez, J. L. Articles by Serrano-Ríos, M. Search for Related Content PubMed PubMed Citation Articles by González-Sánchez, J. L. Articles by Serrano-Ríos, M. Related Collections Endocrinology and Metabolism

Interaction of the –308G/A Promoter Polymorphism of the Tumor Necrosis Factor- Gene with Single-Nucleotide Polymorphism 45 of the Adiponectin Gene: Effect on Serum Adiponectin Concentrations in a Spanish Population

¹ Department of Internal Medicine II, Hospital Clínico San Carlos, Madrid, Spain.
² Department of Medicine, University of Kuopio, Kuopio, Finland.

^aAddress correspondence to this author at: Department of Internal Medicine II, Hospital Clínico San Carlos, Cea Bermúdez 66, 5° G, 28003 Madrid, Spain. Fax 34-91-4429705; e-mail uinvest7.hcsc{at}salud.madrid.org.

Background: We investigated whether interactions of the –308G/A polymorphism in the promoter region of the tumor necrosis factor- (TNF-) gene with single-nucleotide polymorphisms (SNPs) 45 and 276 of the adiponectin gene are associated with circulating adiponectin and soluble TNF- receptor 2 (sTNFR2) concentrations in a Spanish population.

Methods: We performed anthropometric and physiologic measurements in 809 unrelated participants recruited with a simple random sampling approach from respondents to a cross-sectional population-based epidemiologic survey in the province of Segovia in central Spain (Castille).

Results: The 2-h postload glucose and serum insulin concentrations were higher in –308A allele carriers than in –308G/G individuals homozygous for the TNF- gene. Plasma concentrations of sTNFR2 were positively correlated with body mass index, waist-to-hip ratio, and sagittal abdominal diameter among individuals with type 2 diabetes. Individuals with type 2 diabetes and the –308A allele had higher sTNFR2 and lower adiponectin concentrations than –308G homozygotes. Moreover, individuals carrying both the TNF- –308A allele and the G allele of SNP 45 in the adiponectin gene had the highest prevalence of impaired glucose tolerance (adjusted odds ratio, 1.26; 95% confidence interval, 1.01–1.56; P = 0.038) and had lower adiponectin concentrations (ß = –0.090; P = 0.005) than individuals without these genotypes.

Conclusions: Our findings are the first to indicate that a higher incidence of impaired glucose tolerance and low circulating adiponectin concentration may be associated with interaction between the –308G/A promoter polymorphism of the TNF- gene and SNP 45 in the adiponectin gene.

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				C. Menzaghi, V. Trischitta, and A. Doria Genetic Influences of Adiponectin on Insulin Resistance, Type 2 Diabetes, and Cardiovascular Disease Diabetes, May 1, 2007; 56(5): 1198 - 1209. [Abstract] [Full Text] [PDF]