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1 Laboratory Medicine, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. Fax 32-16-347931; e-mail Xavier.Bossuyt{at}uz.kuleuven.ac.be.
Inflammatory bowel disease (IBD) is an enduring disease involving mostly young people, with symptoms of bloody diarrhea and abdominal cramps. Several antibodies have been associated with IBD, the 2 most comprehensively studied being autoantibodies to neutrophils (atypical perinuclear anti-neutrophil cytoplasmic antibodies) and anti-Saccharomyces cerevisiae antibodies. This review focuses on the value of these antibodies for diagnosing IBD, differentiating Crohn disease from ulcerative colitis, indeterminate colitis, monitoring disease, defining clinical phenotypes, predicting response to therapy, and as subclinical markers. Pancreatic antibodies and newly identified anti-microbial antibodies (anti-outer membrane porin C, anti-I2, and anti-flagellin) are also reviewed.
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N. Vermeulen, I. Arijs, S. Joossens, S. Vermeire, S. Clerens, K. Van den Bergh, G. Michiels, L. Arckens, F. Schuit, L. Van Lommel, et al. Anti-{alpha}-enolase Antibodies in Patients with Inflammatory Bowel Disease Clin. Chem., March 1, 2008; 54(3): 534 - 541. [Abstract] [Full Text] [PDF] |
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L. Henckaerts, M. Pierik, M. Joossens, M. Ferrante, P. Rutgeerts, and S. Vermeire Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease Gut, November 1, 2007; 56(11): 1536 - 1542. [Abstract] [Full Text] [PDF] |
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M. Ferrante, L. Henckaerts, M. Joossens, M. Pierik, S. Joossens, N. Dotan, G. L Norman, R. T Altstock, K. Van Steen, P. Rutgeerts, et al. New serological markers in inflammatory bowel disease are associated with complicated disease behaviour Gut, October 1, 2007; 56(10): 1394 - 1403. [Abstract] [Full Text] [PDF] |
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