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Clinical Chemistry 52: 263-269, 2006. First published December 29, 2005; 10.1373/clinchem.2005.057810
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(Clinical Chemistry. 2006;52:263-269.)
© 2006 American Association for Clinical Chemistry, Inc.

General Clinical Chemistry

The Cobalamin-Binding Proteins Transcobalamin and Haptocorrin in Maternal and Cord Blood Sera at Birth

Rima Obeid1, Anne L. Morkbak3, Winfried Munz2, Ebba Nexo3 and Wolfgang Herrmann1,a

1 Department of Clinical Chemistry, Faculty of Medicine, and 3 Department of Obstetrics and Gynaecology, Faculty of Medicine, University Hospital of Saarland, Homburg/Saar, Germany.
2 Department of Clinical Biochemistry, NBG, AS, Aarhus University Hospital, Denmark.

aAddress correspondence to this author at: Department of Clinical Chemistry, Central Laboratory, University of the Saarland, Building 57, 66421 Homburg, Germany. Fax 49-6841-1630703; e-mail kchwher{at}uniklinik-saarland.de.

Background: Two proteins carry vitamin B12 in plasma. Transcobalamin (TC) carries ~25% of total plasma vitamin B12 and is 6% to 20% saturated with cobalamin. Haptocorrin (HC) binds ~80% of total cobalamin and is largely saturated with cobalamin.

Methods: We investigated the distribution and the relationship between concentrations of cobalamin, total and holo forms of TC, and HC in blood samples from pregnant women just before delivery (n = 92) and in cord blood samples from their newborn babies. We also investigated the relationship between these proteins and concentrations of methylmalonic acid (MMA), the functional marker of vitamin B12 status.

Results: Concentrations of total serum cobalamin, total HC, holoHC, and percentage of HC saturation were higher in cord blood than in the maternal blood (mean cobalamin, 268 vs 188 pmol/L; total HC, 648 vs 538 pmol/L; holoHC, 441 vs 237 pmol/L; HC saturation, 70% vs 47%). Moreover, total TC was low in cord blood, whereas both holoTC and TC saturation were higher in cord blood than in the maternal blood (mean total TC, 654 vs 1002 pmol/L; holoTC, 118 vs 53 pmol/L; TC saturation, 19.8% vs 5.4%). Higher maternal serum cobalamin was associated with higher cord blood holoTC and TC saturation (P <0.05). Gestational age was also a significant determinant of baby total TC, TC saturation, total HC, and holoHC.

Conclusion: The close correlation between the amounts of holoTC present in cord blood and in maternal serum supports the importance of maternal cobalamin status for ensuring a sufficient supply to the baby.




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R. A.R. Bowen, S. K. Drake, R. Vanjani, E. D. Huey, J. Grafman, and M. K. Horne III
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