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Clinical Chemistry 52: 504-510, 2006. First published January 19, 2006; 10.1373/clinchem.2005.055798
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(Clinical Chemistry. 2006;52:504-510.)
© 2006 American Association for Clinical Chemistry, Inc.

General Clinical Chemistry

Biological Determinants of and Reference Values for Plasma Interleukin-8, Monocyte Chemoattractant Protein-1, Epidermal Growth Factor, and Vascular Endothelial Growth Factor: Results from the STANISLAS Cohort

Hind Berrahmoune1,2, John V. Lamont3, Bernard Herbeth1,2, Peter S. FitzGerald3 and Sophie Visvikis-Siest1,2,a

1 INSERM U525, Nancy, France.
2 Université Henry Poincaré, Nancy, France.
3 Randox Laboratories, Ltd., Crumlin, United Kingdom.

aAddress correspondence to this author at: Institut National de la Santé et de la Recherche Médicale (INSERM) U525, 30 rue Lionnois, F54000 Nancy, France. Fax 33-3-8332-1322; e-mail Sophie.Visvikis-Siest{at}nancy.inserm.fr.

Background: Interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) are known to be involved in various diseases related to inflammation, vascular remodeling, or growth deregulation. In addition, increases in plasma concentrations of these cytokines appear to provide useful diagnostic and prognostic information. We therefore investigated which factors most strongly influence the biological variations of plasma IL-8, MCP-1, EGF, and VEGF concentrations.

Methods: We used the Evidence® biochip array analyzer to quantify plasma IL-8, MCP-1, EGF, and VEGF concentrations in a subsample of 304 children (age range, 4–17 years) and 540 adults (age range, 18–55 years) from the STANISLAS family study. We also calculated reference intervals for the 4 cytokines.

Results: We found the following associations with plasma marker concentrations: Age, neutrophil count, and glucose concentration were positively associated with IL-8 concentrations in children and adults, as were smoking and platelet count in adults. MCP-1 concentrations were associated with age and smoking in both children and adults, monocyte count in children, and sex and hematocrit in adults. EGF concentrations were associated with platelet count in children and monocyte count and glucose in adults. VEGF concentrations were associated with age in children and adults and platelet count and alanine aminotransferase activity in adults.

Conclusion: Our results for IL-8, MCP-1, EGF, and VEGF may be useful for interpretation of patients’ laboratory results and for understanding the regulation of concentrations of these cytokines in physiologic conditions.




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