Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 52: 827-831, 2006. First published March 16, 2006; 10.1373/clinchem.2005.065441
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
clinchem.2005.065441v1
52/5/827    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gegenhuber, A.
Right arrow Articles by Mueller, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gegenhuber, A.
Right arrow Articles by Mueller, T.
Related Collections
Right arrow Proteomics and Protein Markers
(Clinical Chemistry. 2006;52:827-831.)
© 2006 American Association for Clinical Chemistry, Inc.

Proteomics and Protein Markers

Midregional Pro-A-Type Natriuretic Peptide Measurements for Diagnosis of Acute Destabilized Heart Failure in Short-of-Breath Patients: Comparison with B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP

Alfons Gegenhuber1, Joachim Struck2, Werner Poelz3, Richard Pacher4, Nils G. Morgenthaler2, Andreas Bergmann2, Meinhard Haltmayer5,6 and Thomas Mueller5,a

Departments of1 Internal Medicine and 5 Laboratory Medicine, Konventhospital Barmherzige Brueder, Linz, Austria.
2 Research Department, B.R.A.H.M.S AG, Hennigsdorf/Berlin, Germany.
3 Institute for Applied System Sciences and Statistics, University of Linz, Linz, Austria.
4 Department of Cardiology, Medical University of Vienna, Vienna, Austria.
6 Paracelsus Private Medical University, Salzburg, Austria.

aAddress correspondence to this author at: Department of Laboratory Medicine, Konventhospital Barmherzige Brueder, Seilerstaette 2-4, A-4020 Linz, Austria. Fax 43-732-7677-3799; e-mail thomas.mueller{at}bs-lab.at.

Background: The aim of the present study was to assess the utility of amino-terminal pro-A-type natriuretic peptide (NT-proANP) measurements for the emergency diagnosis of acute destabilized heart failure (HF), using a novel sandwich immunoassay covering midregional epitopes (MR-proANP).

Methods: The retrospective analysis comprised 251 consecutive patients presenting to the emergency department of a tertiary care hospital with dyspnea as a chief complaint. The diagnosis of acute destabilized HF was based on the Framingham score for HF plus echocardiographic evidence of systolic or diastolic dysfunction. A commercially available immunoluminometric assay was used for measurement of MR-proANP plasma concentrations.

Results: Median MR-proANP plasma concentrations were significantly higher in patients with dyspnea attributable to acute destabilized HF (338 pmol/L; n = 137) than in patients with dyspnea attributable to other reasons (98 pmol/L; n = 114; P <0.001). The area under the curve for MR-proANP was 0.876 (SE = 0.022; 95% confidence interval, 0.829–0.914), and the cutoff concentration with the highest diagnostic accuracy was 169 pmol/L (sensitivity, 89%; specificity, 76%; diagnostic accuracy, 83%). In the setting evaluated, diagnostic information obtained by MR-proANP measurements was similar to that obtained with B-type natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) measurements.

Conclusions: MR-proANP measurements may be useful as an aid in the diagnosis of acute destabilized HF in short-of-breath patients presenting to an emergency department. The diagnostic value of MR-proANP appears to be comparable to that of BNP and NT-proBNP.




The following articles in journals at HighWire Press have cited this article:


Home page
 HeartHome page
B Dieplinger, A Gegenhuber, M Haltmayer, and T Mueller
The authors' reply:
Heart, October 1, 2009; 95(19): 1627 - 1627.
[Full Text] [PDF]

Home page
 HeartHome page
B Dieplinger, A Gegenhuber, M Haltmayer, and T Mueller
Evaluation of novel biomarkers for the diagnosis of acute destabilised heart failure in patients with shortness of breath
Heart, September 15, 2009; 95(18): 1508 - 1513.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. Q. Khan, O. Dhillon, D. Kelly, I. B. Squire, J. Struck, P. Quinn, N. G. Morgenthaler, A. Bergmann, J. E. Davies, and L. L. Ng
Plasma N-Terminal B-Type Natriuretic Peptide as an Indicator of Long-Term Survival After Acute Myocardial Infarction: Comparison With Plasma Midregional Pro-Atrial Natriuretic Peptide: The LAMP (Leicester Acute Myocardial Infarction Peptide) Study
J. Am. Coll. Cardiol., May 13, 2008; 51(19): 1857 - 1864.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. von Haehling, E. A. Jankowska, N. G. Morgenthaler, C. Vassanelli, L. Zanolla, P. Rozentryt, G. S. Filippatos, W. Doehner, F. Koehler, J. Papassotiriou, et al.
Comparison of Midregional Pro-Atrial Natriuretic Peptide With N-Terminal Pro-B-Type Natriuretic Peptide in Predicting Survival in Patients With Chronic Heart Failure
J. Am. Coll. Cardiol., November 13, 2007; 50(20): 1973 - 1980.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Emdin, C. Passino, C. Prontera, M. Fontana, R. Poletti, A. Gabutti, C. Mammini, A. Giannoni, L. Zyw, G. Zucchelli, et al.
Comparison of Brain Natriuretic Peptide (BNP) and Amino-Terminal ProBNP for Early Diagnosis of Heart Failure
Clin. Chem., July 1, 2007; 53(7): 1289 - 1297.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Clerico, M. Fontana, L. Zyw, C. Passino, and M. Emdin
Comparison of the Diagnostic Accuracy of Brain Natriuretic Peptide (BNP) and the N-Terminal Part of the Propeptide of BNP Immunoassays in Chronic and Acute Heart Failure: A Systematic Review
Clin. Chem., May 1, 2007; 53(5): 813 - 822.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W.H. W. Tang and G. S. Francis
The Year in Heart Failure
J. Am. Coll. Cardiol., December 19, 2006; 48(12): 2575 - 2583.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the American Association for Clinical Chemistry.