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Clinical Chemistry 52: 1247-1253, 2006. First published May 18, 2006; 10.1373/clinchem.2005.065680
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(Clinical Chemistry. 2006;52:1247-1253.)
© 2006 American Association for Clinical Chemistry, Inc.

Reviews

Gc-Globulin: Roles in Response to Injury

Ursula Meier1,a, Olav Gressner2, Frank Lammert2 and Axel M. Gressner1

1 Institute of Clinical Chemistry and Pathobiochemistry and Central Laboratory, Rheinisch-Westfälische Technische Hochschule (RWTH)–University Hospital Aachen, Aachen, Germany.
2 Department of Internal Medicine I, University of Bonn–University Hospital Bonn, Bonn, Germany.

aAddress correspondence to this author at: Institute of Clinical Chemistry and Pathobiochemistry and Central Laboratory, Rheinisch-Westfälische Technische Hochschule (RWTH)–University Hospital Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany. Fax 49-241-8082512; e-mail umeier{at}ukaachen.de.

Background: Gc-globulin (vitamin D–binding protein) appears to have important functions in addition to its role as a carrier of vitamin D.

Approach: We reviewed recent studies focusing on the pathophysiologic functions and clinical significance of Gc-globulin.

Results: Serum concentrations of Gc-globulin, as determined by immunoassay techniques, are decreased in severe injury. The extent of the decrease may have prognostic significance for patient outcomes. Clinical studies and animal models have shown that Gc-globulin has an important role in the clearance of procoagulant actin from the circulation after its release during cell necrosis and tissue injury. Gc-globulin has other potential roles in responses to acute tissue injury through conversion to a macrophage-activating factor, neutrophil chemotactic activity, and enhancement of C5a-mediated signaling.

Conclusion: Considering the important physiologic roles of Gc-globulin in responses to tissue injury, such as clearance of actin, measurement of Gc-globulin may have value in directing the care of patients in many clinical disorders.






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Copyright © 2006 by the American Association for Clinical Chemistry.