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Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10–18 Years Old

¹ Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
² Isfahan University of Medical Sciences, Isfahan, Iran.
³ Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

^aAddress correspondence to this author at: Preventive Pediatric Cardiology Department, Isfahan Cardiovascular Research Centre, Isfahan University of Medical Sciences, PO Box 81465-1148, Isfahan, Iran. Fax 98-311-3373435; e-mail kroya{at}aap.net or Kelishadi{at}med.mui.ac.ir

Background: This study was undertaken to determine the association of serum C-reactive protein (CRP) with generalized and abdominal obesity, body fat composition, the metabolic syndrome, and oxidative stress markers among young people.

Methods: We conducted a population-based study of 512 young people, aged 10–18 years. We obtained anthropometric and blood pressure measurements. Fasting blood sugar, total cholesterol (TC), HDL-cholesterol, triglycerides, CRP, malondialdehyde (MDA), and conjugated diene (CDE) were quantified. LDL-cholesterol (LDL-C) was calculated for samples with TG 4.52 mmol/L

Results: Mean triglycerides, waist and hip circumferences, percentage body fat, subcutaneous fat, and systolic blood pressure increased significantly with increasing body mass index (BMI). In contrast, the mean LDL and TC were higher in underweight than normal weight individuals, and then increased significantly from normal to higher BMI categories. Mean HDL cholesterol significantly decreased with increasing BMI. Overall, CRP, MDA, and CDE were significantly correlated with measures of abdominal obesity. Serum CRP, MDA, and CDE significantly increased in the upper quartiles of waist circumference. Study participants with higher CRP concentrations were more likely to have metabolic syndrome and high oxidative stress markers.

Conclusion: We found a significant positive association between CRP and oxidative stress markers in healthy young people, as well as an increase in these markers in the upper quartiles of waist circumference, but not BMI. Oxidative stress and CRP may interact in the early inflammatory processes of atherosclerosis.

The following articles in journals at HighWire Press have cited this article:

				R. Kelishadi, M. Hashemi, N. Mohammadifard, S. Asgary, and N. Khavarian Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function after a Lifestyle Modification Trial Among Obese Children Clin. Chem., January 1, 2008; 54(1): 147 - 153. [Abstract] [Full Text] [PDF]