Clinical Chemistry Siemens Point of Care - Urinalysis
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 53: 940-946, 2007. First published March 23, 2007; 10.1373/clinchem.2006.081620
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow 081620.Kazemi Supplemental Data
Right arrow All Versions of this Article:
clinchem.2006.081620v1
53/5/940    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kazemi-Shirazi, L.
Right arrow Articles by Marsik, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kazemi-Shirazi, L.
Right arrow Articles by Marsik, C.
Related Collections
Right arrow General Clinical Chemistry
(Clinical Chemistry. 2007;53:940-946.)
© 2007 American Association for Clinical Chemistry, Inc.

General Clinical Chemistry

Gamma Glutamyltransferase and Long-Term Survival: Is It Just the Liver?

Lili Kazemi-Shirazi1,2,2, Georg Endler1,2, Stefan Winkler3, Thomas Schickbauer1, Oswald Wagner1,a and Claudia Marsik1

1 Institute of Medical and Chemical Laboratory Diagnostics and the Departments of2 Internal Medicine III, Division of Gastroenterology and Hepatology, and3 Internal Medicine I, Division of Infectious Diseases, Medical University of Vienna, Vienna, Austria.

aAddress correspondence to this author at: Medical University of Vienna, Institute of Medical and Chemical Laboratory Diagnostics, Waehringer Guertel 18-20, A-1090 Vienna, Austria. Fax 43-1-40400-5389; e-mail Oswald.wagner{at}meduniwien.ac.at.

Background: Increased gamma glutamyltransferase (GGT) is associated with cardiovascular disease. To date, however, few studies with sufficient sample size and follow-up have investigated the association of GGT with all-cause mortality.

Methods: The relation of GGT to the risk of death was examined in a cohort of 283 438 first attendants (inpatients or outpatients) of the Vienna General Hospital with request for GGT analysis as part of a routine screening panel and was monitored for up to 13 years. To evaluate GGT as a predictor, Cox proportional hazards models were calculated, which were adjusted for age and sex.

Results: In both men and women, GGT above the reference category (GGT ≥9 U/L in women, ≥14 U/L in men) was significantly (P <0.001) associated with all-cause, cancer, hepatobiliary, and vascular mortalities. Hazard ratios (HRs) for men and women were similar in all categories. Among patients who presented with GGT above the reference category, those younger than 30 years had higher all-cause mortality rates than did older individuals (HR 1.5–3.3 vs HR 1–1.3 >80 years, respectively).

Conclusions: GGT is associated with mortality in both men and women, especially in patients younger than 30 years, and even high-normal GGT is a risk factor for all-cause mortality.




The following articles in journals at HighWire Press have cited this article:


Home page
 Alcohol AlcoholHome page
P. Alatalo, H. Koivisto, K. Puukka, J. Hietala, P. Anttila, R. Bloigu, and O. Niemela
Biomarkers of Liver Status in Heavy Drinkers, Moderate Drinkers and Abstainers
Alcohol Alcohol., March 1, 2009; 44(2): 199 - 203.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. M. Strasak, C. C. Kelleher, J. Klenk, L. J. Brant, E. Ruttmann, K. Rapp, H. Concin, G. Diem, K. P. Pfeiffer, H. Ulmer, et al.
Longitudinal Change in Serum Gamma-Glutamyltransferase and Cardiovascular Disease Mortality: A Prospective Population-Based Study in 76 113 Austrian Adults
Arterioscler. Thromb. Vasc. Biol., October 1, 2008; 28(10): 1857 - 1865.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. M. Strasak, K. Rapp, L. J. Brant, W. Hilbe, M. Gregory, W. Oberaigner, E. Ruttmann, H. Concin, G. Diem, K. P. Pfeiffer, et al.
Association of {gamma}-Glutamyltransferase and Risk of Cancer Incidence in Men: A Prospective Study
Cancer Res., May 15, 2008; 68(10): 3970 - 3977.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Association for Clinical Chemistry.