Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 53: 1358-1363, 2007. First published May 10, 2007; 10.1373/clinchem.2006.085258
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow 085258.Supplemental Data
Right arrow All Versions of this Article:
clinchem.2006.085258v1
53/7/1358    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lefkowitz, L. J.
Right arrow Articles by Weese, C. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lefkowitz, L. J.
Right arrow Articles by Weese, C. B.
Related Collections
Right arrow General Clinical Chemistry
Right arrow Drug Monitoring and Toxicology
(Clinical Chemistry. 2007;53:1358-1363.)
© 2007 American Association for Clinical Chemistry, Inc.

General Clinical Chemistry

Intraindividual Stability of Human Erythrocyte Cholinesterase Activity

Lee J. Lefkowitz1,2, Joseph M. Kupina1, Nigel L. Hirth1, Rachel M. Henry1, Georgia Y. Noland2, John Y. Barbee, Jr2, Joey Y. Zhou1 and Coleen B. Weese1,a

1 US Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD.
2 US Army Occupational Health Clinic, Bluegrass Army Depot, Richmond, KY.

aAddress correspondence to this author at: US Army Center for Health Promotion and Preventive Medicine, 5158 Blackhawk Rd., Aberdeen Proving Ground, MD 21010-5403. Fax 410-436-4117; e-mail coleen.weese{at}us.army.mil.

Background: Erythrocyte cholinesterase (RBC-ChE) activities serve as useful and sensitive biomarkers to monitor exposure to cholinesterase-inhibiting substances, such as chemical warfare nerve agents and pesticides. Although the interindividual variation of RBC-ChE is well characterized, the magnitude of intraindividual variation for RBC-ChE remains controversial. An accurate measure of intraindividual variation is critical for establishing the appropriate frequency of RBC-ChE testing.

Methods: We retrospectively tracked the intraindividual variation of RBC-ChE activities among 46 male nerve agent workers from a single US Army depot that participated in a medical surveillance program requiring periodic RBC-ChE monitoring. All RBC-ChE analysis was performed by the same medical laboratory technician by the delta pH method.

Results: A mean of 38 and a median of 37 RBC-ChE measurements were available for each worker. The mean duration of employment for these workers was 20 years (median, 21 years). The mean CV for RBC-ChE in this set of 46 workers was 3.9%. Linear regression analysis of the data for each worker resulted in a mean slope of 0.0010 delta pH units/h per year.

Conclusions: RBC-ChE activities increased in each person by a mean of 0.01 delta pH units/h every 10 years, which is a negligible rate. These findings highlight the stability of RBC-ChE activities over time in a given individual and may have important policy implications regarding the appropriate frequency of RBC-ChE testing.




The following articles in journals at HighWire Press have cited this article:


Home page
 Occup Med (Lond)Home page
V. Ng, D. Koh, A. Wee, and S.-E. Chia
Salivary acetylcholinesterase as a biomarker for organophosphate exposure
Occup. Med., March 1, 2009; 59(2): 120 - 122.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Association for Clinical Chemistry.