Clinical Chemistry
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Clinical Chemistry 55: 175-178, 2009. First published December 1, 2008; 10.1373/clinchem.2008.114231
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(Clinical Chemistry. 2009;55:175-178.)
© 2009 American Association for Clinical Chemistry, Inc.

Brief Communications

Lack of Association of Soluble CD40 Ligand with the Presence of Acute Myocardial Infarction or Ischemic Stroke in the Emergency Department

Michaela Plaikner1, Andreas Peer1, Gerda Falkensammer2, Christoph Schmidauer3, Christoph Pechlaner4, Andrea Griesmacher2, Otmar Pachinger1 and Johannes Mair1,a

1 Department of Internal Medicine, Division of Cardiology, 2 Central Institute for Medical and Chemical Laboratory Diagnostics, 3 Department of Neurology, and 4 Department of Internal Medicine, Division of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria;

aaddress correspondence to this author at: Universitaetsklinik fuer Innere Medizin III – Kardiologie, Anichstrasse 35, A-6020 Innsbruck, Austria. Fax +43 512 504 22767; e-mail Johannes.Mair{at}i-med.ac.at


Abstract

Background: Soluble CD40 ligand (sCD40L) has been proposed as a new risk marker for cardiovascular diseases; however, its possible role as a diagnostic marker in the emergency department (ED) has not yet been investigated.

Methods: We investigated sCD40L for the diagnosis of acute myocardial infarction or ischemic stroke in 1089 consecutive patients (525 males, 564 females; age, 17–98 years; median, 56 years) in an ED treating mainly adults with medical or neurologic emergencies. We used a research assay from Roche Diagnostics to measure sCD40L in heparinized plasma prepared from routinely drawn blood samples.

Results: Intraassay and interassay CVs in our laboratory ranged from 1.6%–4.2% and from 4.4%–4.9%, respectively. A multiple linear regression analysis revealed sCD40L concentration to be significantly associated with C-reactive protein concentration (P = 0.012) and platelet count (P < 0.001). In addition, a subgroup analysis revealed a significant association between smoking and sCD40L concentration (P = 0.006). All other tested variables, including discharge diagnosis, age, sex, and other laboratory variables, showed no significant associations.

Conclusions: In adults presenting to the ED, sCD40L is not useful as a diagnostic marker for acute cardiac, cerebrovascular ischemic, or thromboembolic events.




The following articles in journals at HighWire Press have cited this article:


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 J Am Coll CardiolHome page
C. Antoniades, C. Bakogiannis, D. Tousoulis, A. S. Antonopoulos, and C. Stefanadis
The CD40/CD40 ligand system: linking inflammation with atherothrombosis.
J. Am. Coll. Cardiol., August 18, 2009; 54(8): 669 - 677.
[Abstract] [Full Text] [PDF]


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