Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 55: 2026-2034, 2009. First published September 3, 2009; 10.1373/clinchem.2009.124891
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
clinchem.2009.124891v1
55/11/2026    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Zhang, W.
Right arrow Articles by Hui, R.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, W.
Right arrow Articles by Hui, R.
(Clinical Chemistry. 2009;55:2026-2034.)
© 2009 American Association for Clinical Chemistry, Inc.

Endocrinology and Metabolism

Plasma Uric Acid and Hypertension in a Chinese Community: Prospective Study and Metaanalysis

Weili Zhang1, Kai Sun1, Ying Yang2, Hongye Zhang1, Frank B. Hu3 and Rutai Hui1,a

1 The Key Laboratory for Clinical Cardiovascular Genetics, Cardiovascular Institute and FuWai Hospital, Peking Union Medical College, Beijing, China; 2 QingDao FuWai Hospital, Qingdao, China; 3 Harvard School of Public Health, Boston, MA.

aAddress correspondence to this author at: Cardiovascular Institute and FuWai Hospital, Peking Union Medical College, 167 Beilishilu, Beijing 100037, P. R. China. Fax: 86-10-68331730; E-mail: huirutai{at}sglab.org.

Background: Hyperuricemia has been positively associated with hypertension, but whether this association is independent of adiposity and other cardiovascular risk factors remains a matter of debate.

Methods: We conducted a community-based prospective cohort study comprising 7220 participants (mean age 37 years; 73.8% men) in the Qingdao Port Health and Nutrition Examination Survey in China, who were free from hypertension at study entry in 1999–2000. During 4-year follow-up, 1370 men (19.0%) and 208 women (11.0%) had developed hypertension.

Results: After adjustment for age, body mass index, and other covariates, the relative risks (RRs) of developing hypertension comparing the highest and lowest uric acid quartiles were 1.55 (95% CI 1.10–2.19; P for trend <0.001) for men and 1.91 (1.12–3.25; P for trend <0.001) for women. After additional adjustment for abdominal obesity, the RRs comparing the participants in the highest and lowest quartiles of uric acid were 1.39 (1.16–1.68; P for trend 0.003) for men and 1.85 (1.06–3.24; P for trend 0.006) for women. In joint analysis, compared with those in the lowest uric acid quartile and without abdominal obesity, participants who were in the highest quartile and also had abdominal obesity had a 3.0- and 3.4-fold greater risk of incident hypertension (1.56–3.97 for men and 2.10–3.81 for women, respectively).

Conclusions: These data suggest a positive association between plasma uric acid and incidence of hypertension during short-term follow-up in a Chinese population. The association between hyperuricemia and hypertension was partly mediated by abdominal obesity.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2009 by the American Association for Clinical Chemistry.