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This Article Full Text Full Text (PDF) Supplemental Data All Versions of this Article: clinchem.2009.126706v1 56/2/177    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Anderson, N. L. PubMed PubMed Citation Articles by Anderson, N. L. Related Collections Proteomics and Protein Markers

The Clinical Plasma Proteome: A Survey of Clinical Assays for Proteins in Plasma and Serum

¹ Plasma Proteome Institute, Washington, DC.

Address correspondence to the author at: Plasma Proteome Institute, P.O. Box 53450, Washington, DC 20009-3450. E-mail leighanderson{at}plasmaproteome.org.

Abstract

An analysis of all US Food and Drug Administration (FDA) approvals for protein-based assays through 2008 reveals 109 unique protein targets in plasma or serum, as well as 62 additional tests for peptides, protein posttranslational modifications, protein complexes, autoantibodies against endogenous proteins, and blood cell proteins. A further 96 unique protein targets are assayed in plasma by laboratory-developed tests available for clinical use in the US, yielding a total of 205 proteins that include products of approximately 211 genes (excluding immunoglobulins). These tests provide quantitative measurements for approximately 1% of the human protein gene products, defining a practical clinical plasma proteome. The rate of introduction of new protein analytes has remained essentially flat over the past 15 years, averaging 1.5 new proteins per year (median of 1 per year). This rate falls far short of that needed to support projected medical needs and indicates serious deficiencies in the protein biomarker pipeline, from which no proteomics-discovered analytes have yet emerged.

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