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Clinical Chemistry 6: 168-175, 1960;
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Clinical Chemistry, Vol 6, 168-175, Copyright © 1960 by the American Association for Clinical Chemistry

Effect of Orally Administered Quinine and Quinidine on Apparent Values for Urinary Catecholamines

Sylvan M. Sax 1, Harold E. Waxman 1, Jerome H. Aarons 1, and Harry J. Lynch 1

1 Departments of Pathology and Medicine, The Western Pennsylvania Hospital, Pittsburgh, Pa.

The oral administration of quinine and quinidine results in an apparently increased excretion of catecholamines, the effect being greater following quinine. Marked similarity exists in the fluorescence behavior of postquinine and postquinidine eluates and solutions of the model compound 6-methoxy-4-methylcarbostyril. The possibility that quinine and quinidine carbostyrils are responsible for the observed interference is discussed.

Submitted on October 15, 1959






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