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Clinical Chemistry 6: 537-548, 1960;
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Clinical Chemistry, Vol 6, 537-548, Copyright © 1960 by the American Association for Clinical Chemistry

Fluorimetric Determination of Creatine

Rex B. Conn Jr. 1

1 Department of Laboratory Medicine, University of Minnesota, Minneapolis, Minn.

A new fluorimetric method for determining creatine in serum, blood, and urine is described. The method is based upon the coupling of guanidine compounds with ninhydrin in alkaline solution to produce highly fluorescent products. In degree of sensitivity and simplicity the method possesses several advantages over currently used colorimetric methods, and creatine can be determined in concentrations as low as 1.0 X 10-7M. The serum creatine concentration was found to be 0.41 mg.% in normal adult males, who excrete only small amounts of creatine in the urine.

Submitted on May 13, 1960




The following articles in journals at HighWire Press have cited this article:


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 J. Appl. Physiol.Home page
G. L. Warren, J. M. Fennessy, and M. L. Millard-Stafford
Strength loss after eccentric contractions is unaffected by creatine supplementation
J Appl Physiol, August 1, 2000; 89(2): 557 - 562.
[Abstract] [Full Text] [PDF]


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Copyright © 1960 by the American Association for Clinical Chemistry.