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Clinical Chemistry 6: 549-557, 1960;
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Clinical Chemistry, Vol 6, 549-557, Copyright © 1960 by the American Association for Clinical Chemistry

Study on the Determination of Heavy Water in Plasma or Urine

O. H. Gaebler 1 and Harold C. Choitz 1

1 Edsel B. Ford Institute for Medical Research, Henry Ford Hospital, Detroit.

A technic has been described for determining the excess of deuterium oxide in plasma or urine, by directly measuring 19:18 ratios in vapor from these fluids with a mass spectrometer of suitable design. Although the 19:18 ratio for water varied with sample size and other experimental conditions, the increment in ratio per unit concentration of added D2O remained quite uniform. A virtually linear relationship between the increment in ratio and the concentration of added D2O also facilitated checking the calibration. The time required for flushing out deuterium when a Pyrex inlet system was used could be minimized by carrying out both the calibrations and the analyses in triplicate, without intermediate flushing, but with adherence to a strict time schedule. Results calculated from increments in ratio for the second and third samples of vapor rarely differed from their average value by more than ± 0.8 per cent.

Submitted on February 14, 1960




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