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Clinical Chemistry 7: 130-135, 1961;
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Clinical Chemistry, Vol 7, 130-135, Copyright © 1961 by the American Association for Clinical Chemistry

Method for the Estimation of Phenothiazine Derivatives in Urine and Blood

Charles A. Hetzel 1

1 Research and Development Divisions, Wyeth Laboratories, Inc., Philadelphia, Pa.

A rapid sensitive method for the estimation of phenothiazine type drugs and their metabolites with an intact thiazine ring in biological fluids is presented. The method is based on the calorimetric determination of the yellow nitration products of these compounds formed after their alkaline ether extraction.

Submitted on June 30, 1960






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Copyright © 1961 by the American Association for Clinical Chemistry.