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Clinical Chemistry 7: 284-288, 1961;
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Clinical Chemistry, Vol 7, 284-288, Copyright © 1961 by the American Association for Clinical Chemistry

Determination of Urinary Creatine

Samuel S. Kurohara 1

1 Divisions of Radiation Therapy and Experimental Radiology, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.

A method of separation of creatine using ion-exchange chromatography is described. This method is suitable for serial determinations of urinary creatine despite a small contribution by creatinine and guanidino compounds to the color value of the alpha-naphthol and diacetyl reaction. The creatine coefficients of four patients, determined in duplicates, before and after the induction of creatinuria by X-irradiation are presented to illustrate the applicability of the method described.

Submitted on June 25, 1960






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Copyright © 1961 by the American Association for Clinical Chemistry.