Clinical Chemistry
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Clinical Chemistry 8: 62-66, 1962;
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Clinical Chemistry, Vol 8, 62-66, Copyright © 1962 by the American Association for Clinical Chemistry

An Evaluation of Serum "Trypsin" Tests

Arthur L. Babson 1, Prunella A. Read Williams 1, and George E. Phillips 1

1 Warner-Lambert Research Institute, Morris Plains, New Jersey.

When crystalline trypsin was dissolved at various concentrations in pooled serum, the rates of hydrolysis of alpha-benzoyl-1-arginineamide (BAA) and N-alpha-benzoyl-dl-arginine-beta-naphthylamide (BANA) were not linear functions of the trypsin concentration. Also, the plot of trypsin activity in relation to trypsin concentration differed with different sera. The apparent tryptic activity toward these substrates is felt to be a function of the concentration of serum trypsin inhibitor and, with BANA only, some unidentifed proenzyme which is activated by trypsin. Therefore, it is concluded that it is not feasible to measure serum trypsin concentration with these substrates.

Submitted on April 6, 1961






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Copyright © 1962 by the American Association for Clinical Chemistry.