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Clinical Chemistry 8: 400-404, 1962;
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Clinical Chemistry, Vol 8, 400-404, Copyright © 1962 by the American Association for Clinical Chemistry

The Ultramicro Determination of Salicylates in Biologic Fluids

Albert Hanok 1

1 Department of Biochemistry of the Albert Einstein College of Medicine, Yeshiva University, and the Clinical Chemistry laboratory of the Bronx Municipal Hospital Center, New York 61, N. Y.

A method for determining salicylates in ultramicro volumes of blood, spinal fluid, and urine has been investigated. This method combines the simplicity of one reagent for color development and deproteinization with a high degree of accuracy and precision. Apparent salicylate values in blood and spinal fluid of normal individuals are of the order of 0.7 mg./100 ml.

The application of this method to analysis of capillary samples of blood would be of value in the treatment of salicylate poisoning in children and in the maintenance of therapeutic salicylate levels in pediatric practice.

Submitted on July 19, 1961






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Copyright © 1962 by the American Association for Clinical Chemistry.