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Clinical Chemistry 8: 486-496, 1962;
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Clinical Chemistry, Vol 8, 486-496, Copyright © 1962 by the American Association for Clinical Chemistry

Dehydrogenase of Regenerating Red Blood Cells in Phenylhydrazine Anemia

Max M. Friedman 1, Bernard S. Kahn 1, and Bernard Lapan 1

1 Chemistry Division, and the Dr. Milton J. Goodfriend Laboratory, Department of Laboratories, Lebanon Hospital, New York, N. Y.

Dehydrogenase activities in red blood cells of rabbits made anemic with phenylhydrazine were assayed. These assays were continued at the time of reticulocytosis and followed through the course of in vivo maturation of the reticulocytes to a younger erythrocyte population.

Isocitric, glucose-6-phosphate, and 6-phosphogluconic dehydrogenases were more active in the reticulocytes. Isocitric and glucose-6-phosphate dehydrogenases were also more active in the younger red cell, compared to an average population. Lactic dehydrogenase activity was the same in the reticulocyte, young red cell, and the older red cell.

The significance of these findings is discussed.

Submitted on December 20, 1961






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Copyright © 1962 by the American Association for Clinical Chemistry.