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Clinical Chemistry 8: 579-584, 1962;
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Clinical Chemistry, Vol 8, 579-584, Copyright © 1962 by the American Association for Clinical Chemistry

Serum Factors Causing Abnormal Retardation of the Microelectrophoretic Mobility of the Red Blood Cell During Disease

Antonio Rottino 1 and John Angers 1

1 Hodgkin's Disease Research Laboratory, St. Vincent's Hospital, New York, N. Y.

Erythrocytes of healthy humans migrate at a constant mobility in an electric field. This mobility is retarded in a variety of nonmalignant diseases and almost invariably in malignant neoplasm.

The serum of healthy persons contains a factor that will restore normal mobility to cells with retarded mobility. The serum from both malignant neoplasm and nonmalignant disease contains a factor that will retard the mobility of normally-migrating cells.

The factor in the serum of malignant neoplastic disease can be differentiated from the factor in the serum of nonmalignant disease.

Submitted on July 19, 1961






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Copyright © 1962 by the American Association for Clinical Chemistry.