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Clinical Chemistry 9: 97-101, 1963;
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Clinical Chemistry, Vol 9, 97-101, Copyright © 1963 by the American Association for Clinical Chemistry

Spinal-Fluid Protein Determination for the Differentiation of Neurologic Disorders

N. M. Papadopoulos 1, W. C. Hess 2, D. O'Doherly 2, and L. Wakeman 2

1 Medical College of Virginia, P.O. Box 726, Richmond 19, Va.
2 Departments of Biological Chemistry and Neurology, Georgetown University Schools of Medicine and Dentistry, Washigton, D. C.

A simple chemical test previously described for the determination of total protein and -globulin was applied to the analysis of spinal fluid specimens (CSF) from non-neurologic and a variety of neurologic disorders. On the basis of the chemical findings, the pathologic specimens analyzed were divided into three groups: (a) nonneurologic and some neurologic conditions with a normal CSF total protein and -globulin concentration; (b) demyelinating disorders with a normal total protein and elevated b.gamma;-globulin concentration; and (c) degenerative and infectious with an elevated total protein and -globulin. A good correlation between chemical findings and clinical observation was obtained.

Submitted on December 28, 1961






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Copyright © 1963 by the American Association for Clinical Chemistry.