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Clinical Chemistry 9: 266-273, 1963;
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Clinical Chemistry, Vol 9, 266-273, Copyright © 1963 by the American Association for Clinical Chemistry

Changes in the Serum Protein Levels During Wound Tissue Regeneration

Lilita DiLallo 1, Harold B. Haley 1, and Martin B. Williamson 1

1 Departments of Biochemistry and Surgery, Graduate School and Stritch School of Medicine, Loyola University, Chicago 12, Illinois.

The effect of wounding and formation of regenerating wound tissue on the level of the serum proteins was studied in rats on a protein-free diet. It was found that the level of the globulin component having the third greatest electrophoretic mobility, probably part of the alpha2-globulin fraction, rose about 60% within 3 days after wounding and did not begin to return to normal until about 10 days later. Concomitantly, the level of the globulin with least mobility, presumably the -globulin component, decreased about 35% and also began to return to normal within 2 weeks after wounding. Varying the rate of healing, by the addition of protein or methionine to the diet, had no effect on the changes in the serum globulin levels. The newly formed alpha2-globulins were shown to be distinct from fetuin.

Submitted on April 19, 1962






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Copyright © 1963 by the American Association for Clinical Chemistry.