Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 9: 428-437, 1963;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Homer, G. M.
Right arrow Articles by Zipf, R. E.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Homer, G. M.
Right arrow Articles by Zipf, R. E.

Clinical Chemistry, Vol 9, 428-437, Copyright © 1963 by the American Association for Clinical Chemistry

A Spectrophotometric Method for Measuring Serum Trypsin Inhibitor Capacity

George M. Homer 1, Bernard J. Katchman 1, and Robert E. Zipf 1

1 Department of Research, Miami Valley Hospital, Dayton, Ohio.

The spectrophotometric method of Schwert and Takenaka (11) for the assay of trypsin esterolytic activity has been modified for the measurement of the trypsin inhibitor capacity of serum. An average value of 0.99 mg. of trypsin inhibited per milliliter of serum (3 S.D. = ±0.30) was determined for 50 control subjects. Patient serum assay values determined with this method have been found similar to those determined with the modified Kunitz method using l131-labeled casein as the substrate-in the normal range for a variety of pathologic conditions and in the elevated range for abnormalities of the pancreas and generalized cancer conditions. From the standpoints of accuracy, simplicity, and speed this technic is believed to be an improvement over previous methods for the measurement of this serum variable.

Submitted on March 5, 1962






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1963 by the American Association for Clinical Chemistry.