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Clinical Chemistry 9: 717-726, 1963;
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Clinical Chemistry, Vol 9, 717-726, Copyright © 1963 by the American Association for Clinical Chemistry

The Renal Clearance of Sodium Pentaborate in Mice and Men

Lee E. Farr 1 and T. Konikowski 1

1 Section of Nuclear Medicine of the University of Texas M. D. Anderson Hospital and Tumor Institute, Houston 25, Texas.

The renal blood clearance of sodium pentaborate was observed in 8 patients undergoing neutron capture therapy for intracranial malignant tumors and was found to average 39.1 ml./min. per 1.73 sq. m. surface area.

The renal blood clearance was calculated for mice receiving sodium pentaborate intravenously in dosages of 25 µ.g./gm. body weight and 100 µg./gm., calculated as boron. The average clearance for the mice receiving the larger dose was 0.207 ml./min. for a 21-gm. mouse. The average clearance for the mice receiving the smaller dose was 0.192 ml./min. per 21-gm. mouse.

For the mouse, clearance calculated for a surface area of 1.73 sq. m., as was used in man, averages 40 ml./min.

No toxic effects on renal function were observed in mice at the higher dosage.




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The Effect of Pregnancy on Renal Clearance of Boron in Rats Given Boric Acid Orally
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[Abstract] [Full Text] [PDF]


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