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Clinical Chemistry 43: 193a-195a, 1997;
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(Clinical Chemistry. 1997;43:193A-195.)
© 1997 American Association for Clinical Chemistry, Inc.

Letters

Increased Fatty Acid-Binding Protein Concentration in Plasma of Patients with Chronic Renal Failure

Jan Górski1,a, Wim T. Hermens2, Jacek Borawski3, Michal Mysliwiec3 and Jan F. C. Glatz2

1 Dept. of Physiol.,
2 Cardiovasc. Res. Inst. (CARIM),
3 Dept. of Nephrol., Med. School of Bialystok, 15–230 Bialystok, Poland, Univ. of Limburg, P.O. Box 616, 6200 MD Maastricht, The Netherlands
a Author for correspondence.


To the Editor:

The soluble cytoplasm of most cells contains low-molecular-mass (14–15 kDa) proteins able to bind long-chain unesterified fatty acids. Of these so-called fatty acid-binding proteins (FABP), nine different types have been identified (1)(2). Heart and skeletal muscles contain the same type of FABP [referred to as heart-type (H)-FABP] (1)(2), but its concentration in the heart is severalfold higher than that in the skeletal muscles (3). The concentration of FABP in the plasma of healthy persons is relatively low (2–6 µg · L-1) (4). FABP is released from the heart early after the onset of infarction, whereafter its plasma concentration increases manyfold (3)(4)(5)(6). Increased excretion of FABP in urine also occurs after infarction (5)(7). Several recent studies indicate the usefulness of the plasma FABP concentration as an early biochemical marker for myocardial infarction diagnosis (3)(5)(7). However, to interpret properly the values of plasma FABP concentration, one has to take into account not only its source and rate of release into plasma but also its elimination from plasma. It is obvious that any change in the clearance rate of FABP would affect its plasma concentration, and thus may lead to erroneous interpretation. Kleine et al. (8) reported a patient with acute myocardial infarction and severe renal . . . [Full Text of this Article]


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