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Clinical Chemistry 43: 2017-2018, 1997;
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(Clinical Chemistry. 1997;43:2017-2018.)
© 1997 American Association for Clinical Chemistry, Inc.

Editorial

C-Reactive Protein—Undervalued, Underutilized

Raymond Gambino

Quest Diagnostics Inc., 1 Malcolm Ave., Teterboro, NJ 07608-1070, Fax 201-393-5903, e-mail Doclab@aol.com

Tissue injury or infection leads to an increase in the serum concentration of a number of analytes, and to a decrease in the serum concentration of several others (1)(2). The change in concentration is referred to as the acute-phase response. Serum analytes that increase in concentration include C-reactive protein (CRP), serum amyloid A, fibrinogen, haptoglobin, ceruloplasmin, copper, interleukin-6, polypeptide-specific antigen, neopterin, and ferritin (3)(4)(5)(6). Analytes that decrease in concentration include transferrin and iron (6).

CRP is a noteworthy member of this group because of the speed and degree to which its concentration increases after a variety of inflammatory states or injuries to tissues—including myocardial injury or infarction (2). CRP was discovered in 1930 by William Tillet and Thomas Francis at the Rockefeller Institute (7). They extracted a protein from the sera of patients with pneumococcal pneumonia that coprecipitated with the C polysaccharide derived from the cell wall of the pneumococcus. Because the reaction between the protein and the polysaccharide was so specific they named the protein C-reactive protein.

The original test was a simple precipitin . . . [Full Text of this Article]


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 Arch SurgHome page
M. A. Zimmerman, C. H. Selzman, C. Cothren, A. C. Sorensen, C. D. Raeburn, and A. H. Harken
Diagnostic Implications of C-Reactive Protein
Arch Surg, February 1, 2003; 138(2): 220 - 224.
[Abstract] [Full Text] [PDF]


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