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Clinical Chemistry 43: 845-847, 1997;
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(Clinical Chemistry. 1997;43:845-847.)
© 1997 American Association for Clinical Chemistry, Inc.

Technical Briefs

Changes in Plasma Metallothionein-1, Interleukin-6, and C-Reactive Protein in Patients After Elective Surgery

Durojaye F. Akintola1,4, Barry Sampson1,a, Jacky Burrin2, Adam Fleck1, Christopher Price2 and George Hall3

1 Dept. of Chem. Pathol., Charing Cross & Westminster Med. Sch., London, W6 8RF, UK;
2 Dept. of Clin. Biochem., London Hosp. Med. Coll., London, E1 2AD, UK;
3 Dept. of Anesthesia, St George's Hosp. Med. Sch., Cranmer Terr., London, SW17 0RE, UK.;
4 present address: Med. Res. Council, Radiobiol. Unit, Chilton, Didcot Oxfordshire, OX11 0RD, UK;
a author for correspondence: fax (+44)-181-846-7007, e-mail b.sampson@cxwms.ac.uk

Surgical trauma is a stimulus for the acute-phase response (APR), which is thought to be mediated by cytokines such as interleukin-6 (IL-6) (1). Features of the APR include changes in plasma concentrations of proteins such as C-reactive protein (CRP) and albumin and a lowering of plasma Zn and Fe concentrations (2). The metallothioneins (MTs), a family of metal-binding proteins, are also likely to be increased during the APR. Indeed, MT-1 and MT-2 genes are responsive to a wide variety of stimuli, including metals, cytokines, glucocorticoid hormones, and stress (3)(4).

We previously reported a sevenfold increase in circulating MT-1 concentrations 24–48 h after elective surgery (5), confirming observations in animal experiments that MT can act as an acute-phase reactant (6)(7). We also previously showed (8) that extradural anesthesia added to general anesthesia resulted in lower concentrations of cortisol and growth hormone than did general anesthesia alone, but IL-6, CRP, and Zn concentrations did not change significantly.

Here, we have investigated the time course of the changes in plasma concentrations of MT-1, CRP, and IL-6 in patients undergoing elective surgery. We also studied the effects of extradural blockade in addition to general . . . [Full Text of this Article]


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