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Clinical Chemistry 43: 847-848, 1997;
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(Clinical Chemistry. 1997;43:847-848.)
© 1997 American Association for Clinical Chemistry, Inc.

Technical Briefs

Immunoreactive Prostate-Specific Antigen in Pleural Effusions

Ferdinando Mannello1,a, Giovanni Miragoli2, Giuseppe Bianchi3 and Giancarlo Gazzanelli1

1 Ist. Istol. & Anal. Lab., Facoltà Sci., MFN Università, Via E. Zeppi, 61029 Urbino, Italia;
2 Div. Med., and
3 Lab. Anal. Ospedale Civile, Urbino, Italia;
a author for correspondence: fax +39-722-322370, e-mail citometria@fis.uniurb.it

Prostate-specific antigen (PSA) is a serine protease, first identified in 1970 (1) and nowadays widely used for early detection and monitoring of prostate cancer (2). Although previously thought to be produced exclusively by the epithelial cells of the prostate (3), at present PSA is considered a widespread biochemical marker produced and secreted in several biological fluids, by both normal and tumor tissues (e.g., (4)(5)(6)(7)(8)(9)(10)(11)(12)). In blood, complexes form between PSA and serine protease inhibitors, such as {alpha}1-antichymotrypsin and {alpha}2-macroglobulin (2)(3)(4). Free PSA also exists in serum, even though its increased concentration in female serum is a matter of recent debate (12)(13)(14)(15)(16).

Considering the immunoreactivity of PSA in tumors of the lung (7)(8), we undertook the study of the PSA distribution and expression in pleural effusions collected from 68 women, ages 60 ± 11 . . . [Full Text of this Article]


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Copyright © 1997 by the American Association for Clinical Chemistry.