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Clinical Chemistry 43: 1246, 1997;
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(Clinical Chemistry. 1997;43:1246.)
© 1997 American Association for Clinical Chemistry, Inc.

Letters

Hydrogen Peroxide Interferes with Detection of Nitric Oxide by an Electrochemical Method

Sohji Nagasea, Norio Ohkoshi, Atsushi Ueda, Kazumasa Aoyagi and Akio Koyama

Dept. of Internal Med., Inst. of Clinical Med., Univ. of Tsukuba, 1-1-1 Ten-nodai, Tsukuba, Ibaraki 305, Japan
a Author for correspondence.


To the Editor:

Nitric oxide (NO) is a biologically active molecule synthesized from L-arginine in the presence of NO synthetase. Methods to quantify NO include those that use the Griess reaction, chemiluminescence, electron spin resonance, oxygen probing, and electrochemical detection using a porphyrin-based microsensor (1). The latter method is advantageous for this labile molecule in real-time measurement and sensitivity (1)(2). As the preparation of the microsensor is difficult, the . . . [Full Text of this Article]


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Copyright © 1997 by the American Association for Clinical Chemistry.