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Clinical Chemistry 44: 7-9, 1998;
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(Clinical Chemistry. 1998;44:7-9.)
© 1998 American Association for Clinical Chemistry, Inc.

Editoral

Circulating Transferrin Receptor Assay—Coming of Age

Barry S. Skikne

University of Kansas Medical Center, Department of Medicine, Division of Hematology, 3901 Rainbow Blvd., Kansas City, KS 66160, Fax (913) 588-3996

Transferrin receptors are transmembrane proteins present on the surface of most cells. Under normal circumstances, the iron required for cellular metabolism is acquired via transferrin receptors. Several recent reviews detail the methods of iron acquisition, the intracellular throughput of transferrin receptors, and the controlling mechanisms in the cell`s quest to acquire and store iron (1)(2)(3). The cells of different organ systems show considerable differences in the concentration of cellular transferrin receptor, the highest concentrations being found in cells of organs with the highest iron requirements, such as the erythroid bone marrow and placenta (4). The concentration of cell surface transferrin receptor is carefully regulated by transferrin receptor mRNA according to the internal iron content of the cell and its individual iron requirements. Iron-deficient cells contain increased numbers of receptor, while receptor numbers are downregulated in iron-replete cells (4)(5). Transferrin receptor was identified in serum (6) after investigators recognized that the molecule was secreted into culture media in reticulocyte and erythroleukemia cell models (7)(8), and the concentrations of secreted receptor were found to correlate with the total receptor content of the cells. Subsequent studies showed that serum concentrations of transferrin receptor increase in iron-deficiency anemia, making it a useful marker in the diagnosis of microcytic anemias (9). Circulating transferrin receptor is a truncated form of tissue receptor (10), produced by proteolytic cleavage of cellular receptor, and for the most part circulates attached to transferrin (11)(12).

The reference interval for concentration of circulating receptor varies between different assay systems, depending on the choice of calibrators. In this issue of Clinical Chemistry, the transferrin receptor assay recently approved by the US Food and Drug Administration is . . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


Home page
 Annals of Clinical & Laboratory ScienceHome page
J. W. Choi
Sensitivity, Specificity, and Predictive Value of Serum Soluble Transferrin Receptor at Different Stages of Iron Deficiency
Ann. Clin. Lab. Sci., October 1, 2005; 35(4): 435 - 439.
[Abstract] [Full Text] [PDF]

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T. I. Takala, P. Suominen, R. Isoaho, S.-L. Kivela, M. Lopponen, O. Peltola, A. Rajamaki, and K. Irjala
Iron-Replete Reference Intervals to Increase Sensitivity of Hematologic and Iron Status Laboratory Tests in the Elderly
Clin. Chem., September 1, 2002; 48(9): 1586 - 1589.
[Full Text] [PDF]

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P. Suominen, A. Virtanen, M. Lehtonen-Veromaa, O. J. Heinonen, T. T. Salmi, M. Alanen, T. Mottonen, A. Rajamaki, and K. Irjala
Regression-based Reference Limits for Serum Transferrin Receptor in Children 6 Months to 16 Years of Age
Clin. Chem., May 1, 2001; 47(5): 935 - 937.
[Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. Olivares, T. Walter, J. D Cook, E. Hertrampf, and F. Pizarro
Usefulness of serum transferrin receptor and serum ferritin in diagnosis of iron deficiency in infancy
Am. J. Clinical Nutrition, November 1, 2000; 72(5): 1191 - 1195.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. T. Goodnough, B. Skikne, and C. Brugnara
Erythropoietin, iron, and erythropoiesis
Blood, August 1, 2000; 96(3): 823 - 833.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. W. Choi, M. W. Im, and S. H. Pai
Serum Transferrin Receptor Concentrations during Normal Pregnancy
Clin. Chem., May 1, 2000; 46(5): 725 - 727.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. W. Choi, S. H. Pai, M. W. Im, and S. K. Kim
Change in Transferrin Receptor Concentrations with Age
Clin. Chem., September 1, 1999; 45(9): 1562 - 1563.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. Suominen, K. Punnonen, A. Rajamaki, R. Majuri, V. Hanninen, and K. Irjala
Automated Immunoturbidimetric Method for Measuring Serum Transferrin Receptor
Clin. Chem., August 1, 1999; 45(8): 1302 - 1305.
[Full Text] [PDF]


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