Clinical Chemistry
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Clinical Chemistry 44: 2226-2227, 1998;
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(Clinical Chemistry. 1998;44:2226-2227.)
© 1998 American Association for Clinical Chemistry, Inc.

Letters

Diurnal Variability and in Vitro Stability of Carbohydrate-deficient Transferrin

Ola Mårtensson, Eva Schink, and Ragnhild Brandta

Pharmacia & Upjohn Diagnostics AB, Alcohol Related Diseases, S-75182 Uppsala, Sweden
a Author for correspondence. Fax 46-18 16 63 89; e-mail ragnhild.brandt@eu.pnu.com.


To the Editor:

Transferrin isoforms with pI values >=5.7, known as carbohydrate-deficient transferrin (CDT), are present in increased concentrations in the serum of patients with current alcohol abuse. CDT has been found to be a specific and sensitive marker for detection and monitoring of high and continual alcohol consumption (1). The clinical performance of CDT has been studied using various techniques for analysis but also using various conditions for serum sample collection and sample storage. The biological (non-alcohol-influenced) variation over time has been found to be low (2). We have studied the diurnal variability of CDT and the effect of sample storage conditions in the commercial CDTect assays.

Blood was collected by venipuncture and allowed to clot at room temperature. The serum samples were separated by centrifugation, and 1-mL portions were aliquoted into polypropylene tubes (Sarstedt). CDT was measured by duplicate determinations in CDTect® RIA or CDTect EIA (Pharmacia & Upjohn Diagnostics AB). Results are expressed as units per liter. In an evaluation performed on 76 . . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


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 Alcohol AlcoholHome page
J. P. Bergstrom and A. Helander
Clinical Characteristics of Carbohydrate-Deficient Transferrin (%Disialotransferrin) Measured by HPLC: Sensitivity, Specificity, Gender Effects, and Relationship with other Alcohol Biomarkers
Alcohol Alcohol., July 1, 2008; 43(4): 436 - 441.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
J. B. Whitfield, V. Dy, P. A.F. Madden, A. C. Heath, N. G. Martin, and G. W. Montgomery
Measuring Carbohydrate-Deficient Transferrin by Direct Immunoassay: Factors Affecting Diagnostic Sensitivity for Excessive Alcohol Intake
Clin. Chem., July 1, 2008; 54(7): 1158 - 1165.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
B. M.R. Appenzeller and R. Wennig
Altered Distribution of Transferrin Isoforms According to Serum Storage Conditions
Clin. Chem., November 1, 2005; 51(11): 2159 - 2162.
[Full Text] [PDF]

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 Clin. Chem.Home page
A. Helander, A. Husa, and J.-O. Jeppsson
Improved HPLC Method for Carbohydrate-deficient Transferrin in Serum
Clin. Chem., November 1, 2003; 49(11): 1881 - 1890.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
A. Helander, G. Eriksson, H. Stibler, and J.-O. Jeppsson
Interference of Transferrin Isoform Types with Carbohydrate-deficient Transferrin Quantification in the Identification of Alcohol Abuse
Clin. Chem., July 1, 2001; 47(7): 1225 - 1233.
[Abstract] [Full Text] [PDF]


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