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Clinical Chemistry 44: 2234-2237, 1998;
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(Clinical Chemistry. 1998;44:2234-2237.)
© 1998 American Association for Clinical Chemistry, Inc.


AACC 50th Anniversary Retrospective

Citation Classics in Lipid Measurement and Applications

Antonio M. Gotto1,a, and Gerald R. Cooper2

1 Department of Medicine, Weill Medical College, of Cornell University, New York, NY 10021,
2 Division of Environmental Health, Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341-3724
a Address correspondence to this author at: c/o Jesse Jou, Weill Medical College of Cornell University, 445 East 69th Street, Olin Hall, Room 205, New York, NY 10021. Fax 212-746-8200; e-mail jjou@mail.med.cornell.edu.

In 1998 the AACC celebrates its 50th anniversary. Thus, we are honored to call attention to the outstanding professional contributions of the journal Clinical Chemistry over the years by pointing out the citation classics that have been published in its pages. By the end of 1995, 31 articles in Clinical Chemistry had been cited more than 300 times (1). Thirty of these articles were still being cited in 1995, and some are still cited to the present day. These 31 papers are distributed in multiple areas of biological sciences, and in particular: lipids, 8 papers (2)(3)(4)(5)(6)(7)(8)(9); endocrinology, 2 papers; clinical enzymology, 4 papers; intermediary metabolism, 6 papers; renal function, 2 papers; cancer, 1 paper; and calcium metabolism, 3 papers. Publications on methodology research and laboratory applications of lipid, lipoprotein, and apolipoprotein measurements in clinical investigations and epidemiologic trials have had a major impact on research of lipid metabolism and cardiovascular medicine (2)(3)(4)(5)(6)(7)(8)(9). The combined efforts of epidemiologists, clinicians, and laboratorians have produced classic publications on the understanding of lipid metabolic disorders, have stimulated development of new novel equipment and methodology, and have helped to establish the development of beneficial preventive and control measures for diseases of the heart and blood vessels.

The cited lipid papers published in Clinical Chemistry included mainly the original papers on measurement of lipoproteins, enzymatic measurements of cholesterol and triglycerides, and immunoassays of apolipoproteins. The method used most widely today for estimation of the concentration of LDL-cholesterol (LDL-C) in both clinical and research laboratories arose from the publication of Friedewald et al. (2) that showed that the serum concentration of . . . [Full Text of this Article]


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