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Clinical Chemistry 44: 895a-896a, 1998;
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(Clinical Chemistry. 1998;44:895-896.)
© 1998 American Association for Clinical Chemistry, Inc.

Letters

PSA Concentrations in Seminal Plasma

Tang J. Wang1,a, Harry G. Rittenhouse1, Robert L Wolfert1, Charles M. Lynne2, and Nancy L. Brackett2

1 Dept. of Res. and Dev., Hybritech Incorporated, subsidiary of Beckman Instruments, Inc., San Diego, CA 92196,
2 The Miami Project to Cure Paralysis, and the Dept. of Urol., Univ. of Miami School of Med., Miami, FL 33136
a Author for correspondence. Hybritech Incorporated, P.O. Box 269009, San Diego, CA 92196-9006. Fax 619-621-4610.


To the Editor:

Prostate specific antigen (PSA) is an important tumor marker for the detection and monitoring of prostate cancer. PSA is secreted by the prostatic epithelial cells into the lumen of the prostate duct during the formation of seminal plasma. PSA is a 30 kDa serine protease that cleaves biological substrates in seminal fluid, including seminogelin I, seminogelin II, and fibronectin, into small peptides, resulting in increased sperm motility (1)(2)(3)(4). PSA has also been shown to cleave other biological substrates, including insulin-like growth factor-binding protein-3 and laminin, . . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
Y. Fujii, S. Kawakami, Y. Okada, Y. Kageyama, and K. Kihara
Regulation of prostate-specific antigen by activin A in prostate cancer LNCaP cells
Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E927 - E931.
[Abstract] [Full Text] [PDF]


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