Clinical Chemistry
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Clinical Chemistry 44: 905, 1998;
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(Clinical Chemistry. 1998;44:905.)
© 1998 American Association for Clinical Chemistry, Inc.

Editorial

Low Serum Creatine Kinase Activity

Sidney B. Rosalki

Unilabs, Unilabs Clinical Pathology, Bewlay House, 32 Jamestown Rd., London NW1 7BY, UK

Subnormal activity of creatine kinase (CK, ATP: creatine N-phosphotransferase, EC 2.7.3.2) in serum has been observed in a variety of clinical conditions. Subnormal activity may be found as a consequence of diminished efflux of the muscle enzyme into serum from reduced physical activity caused by illness or advanced age or may result from reduced muscle mass accompanying muscle wasting or cachectic states. Low serum CK values reported in acute viral hepatitis have been explained on the basis of reduced physical activity because these patients have been confined to bed for therapeutic reasons or because of the severity of the illness (1). Low CK activities in patients with alcoholic liver disease (2) have been considered to reflect the reduced muscle mass commonly observed in alcoholics.

Reduced serum CK activity has also been observed in patients with connective tissue . . . [Full Text of this Article]


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The following articles in journals at HighWire Press have cited this article:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
K Nozaki and A Pestronk
High aldolase with normal creatine kinase in serum predicts a myopathy with perimysial pathology
J. Neurol. Neurosurg. Psychiatry, August 1, 2009; 80(8): 904 - 908.
[Abstract] [Full Text] [PDF]

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Roberto Rodriguez
Clinical Chemistry Online, 24 Jul 2007 [Full text]

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