Clinical Chemistry
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Clinical Chemistry 45: 682-683, 1999;
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(Clinical Chemistry. 1999;45:682-683.)
© 1999 American Association for Clinical Chemistry, Inc.

Technical Briefs

Different Behaviors of Serum and Urinary CrossLaps ELISA in the Assessment of Bone Resorption in Healthy Girls

Maria Luisa Traba, Jesús A. Calero, Cioly Méndez-Dávila, Carmen García-Moreno and Concepción de la Piedraa

a address correspondence to this author at: Fundación Jiménez Díaz, Laboratorio de Bioquímica, Sección Metabolismo Mineral y Óseo, Avda Reyes Católicos 2, 28040 Madrid, Spain

Many fragments derived from collagen I degradation come to serum during bone resorption. The characterization of these fragments and the development of assays that can measure them are the basis of most of the biochemical markers of bone resorption. One of these fragments consists of two cross-linked amino acid sequences derived from the C-terminal telopeptide region of type I collagen {alpha}1 chains. Fragments containing the sequence EKAH-DGGR (CTX), with a DG site being either nonisomerized ({alpha}-CTX) or ß-isomerized (ß-CTX) were identified. Pyridinoline, deoxypyridinoline, and other cross-links linked both telopeptides (Fig. 1 ) (1). Recent reports have suggested that the proportions of nonisomerized and ß-isomerized fragments depend on bone age (1).



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  		Figure 1. Heterogeneity of urinary degradation products of C-terminal telopeptides derived from the {alpha}1 chain of human type I collagen.

There are two available assays that can measure the ß-isomer form of the CTX epitope: urinary CrossLapsTM ELISA (2), and Serum CrossLaps One Step ELISA (3), both from . . . [Full Text of this Article]


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