Clinical Chemistry
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Clinical Chemistry 45: 1100a-1102a, 1999;
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(Clinical Chemistry. 1999;45:1100A-1102.)
© 1999 American Association for Clinical Chemistry, Inc.

Letters

Serum {gamma}-Glutamyltransferase Isoform Complexed to LDL in the Diagnosis of Small Hepatocellular Carcinoma

Giuseppe Castaldo1,2, Mariano Intrieri1,2, Luigi Castellano3, Ilario de Sio3, Camillo Del Vecchio Blanco3, Lucia Sacchetti2 and Francesco Salvatore2,a

1 Facoltà di Scienze Matematiche, Fisiche e Naturali, Università del Molise, I-86170 Isernia, Italy

2 Centro di Ingegneria Genetica Scarl, and, Dipartimento di Biochimica, e Biotecnologie Mediche, Facoltà di Medicina e Chirurgia, Università di Napoli "Federico II", I-80131 Naples, Italy

3 Cattedra di Fisiopatologia Digestiva, Seconda Università di Napoli, I-80131 Naples, Italy
a Address correspondence to this author at: Dipartimento di Biochimica e Biotecnologie Mediche, Via S. Pansini, 5, I-80131, Naples, Italy. E-mail salvator@unina.it.


To the Editor:

Up to one-third of cirrhoses evolve into hepatocellular carcinoma (HCC), with ~90% of these cases developing on a preexisting cirrhosis (1). However, the detection of early-stage neoplastic transformation remains a challenge. In a recent series of studies, we reported that multivariate discriminant functions based on the serum concentrations of various biochemical indexes efficiently discriminate between chronic hepatobiliary diseases at different stages of their natural history (2)(3)(4). The multivariate analysis also allowed us to detect the neoplastic evolution in five of six cirrhotic patients ~6 months earlier than instrumental approaches (2). This result prompted us to evaluate the efficiency of serum biochemical indexes in detecting small HCC, i.e., <3 cm . . . [Full Text of this Article]


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Copyright © 1999 by the American Association for Clinical Chemistry.