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Clinical Chemistry 45: 1578, 1999;
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(Clinical Chemistry. 1999;45:1578.)
© 1999 American Association for Clinical Chemistry, Inc.

Letters

Mass Spectrometry of Nucleic Acids

Norman H.L. Chiu1,2,a and Charles R. Cantor1,2

1 Sequenom Inc., 11555 Sorrento Valley Rd., San Diego, CA 92121

2 Boston University, Center for Advanced Biotechnology, 36 Cummington St., Boston, MA 02215
a Author for correspondence. Fax 619-350-9237; e-mail nchiu@sequenom.com.


To the Editor:

We read with interest the review by Kricka (1) on nucleic acid detection technologies, in which he mentioned that nucleic acids do not have any intrinsic properties for direct detection. In response to this, we would like to point out the determination of intrinsic molecular weights of nucleic acids using mass spectrometry (MS) has been widely accepted as one of the most accurate methods to detect nucleic . . . [Full Text of this Article]


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