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Clinical Chemistry 45: 1676-1678, 1999;
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(Clinical Chemistry. 1999;45:1676-1678.)
© 1999 American Association for Clinical Chemistry, Inc.

Oak Ridge Poster Sessions

RAMPTM: A Rapid, Quantitative Whole Blood Immunochromatographic Platform for Point-of-Care Testing

Donald E. Brooks1,2,3,a, Dana V. Devine1,2, Paul C. Harris1, Joanne E. Harris1, Mark E. Miller4, Andrew D. Olal1, Linda J. Spiller1 and Zongen C. Xie1

1 Response Biomedical Corp., Vancouver, British Columbia, Canada V5J 5J1;
2 Pathology and Laboratory Medicine and
3 Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5;
4 Datrend Systems Inc., Delta, British Columbia, Canada;
a address correspondence to this author at: Department of Pathology and Laboratory Medicine, University of British Columbia G131 ACU, 2211 Westbrook Mall, Vancouver BC, Canada V6T 2B5

The Rapid Analyte Measurement Platform (RAMPTM) is an enabling immunodiagnostic platform for quantitative analysis of a wide variety of analytes. Consisting of an immunochromatographic strip in a disposable cartridge and a scanning dual wavelength fluorescence reader, RAMP takes advantage of the inherent simplicity of lateral flow immunochromatography while providing a quantitative measurement of analyte concentration. Using 2–3 drops of whole blood, a test can be completed in 5 min by placing the blood on the cartridge and placing the cartridge in the fluorescence reader. No training or sample measurement is needed. The system has a low manufacturing cost and a short development time per assay. A patent was issued on the system in the US in May 1998 (1).

The criteria for point-of-care testing (2) are affordable cost, a disposable device, and/or minimal maintenance and minimal technical expertise required to perform tests. The sample should be whole blood, low volume, unmetered, and applied directly into the instrument or disposable. There needs to be a simple "goof-proof" strategy for recording collection time and result reporting, a simple strategy for calibration and quality control, data transfer capability compatible with the laboratory or hospital information system and a positive identification and specimen-tracking strategy that eliminates . . . [Full Text of this Article]


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The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
S. Choi, E. Y. Choi, H. S. Kim, and S. W. Oh
On-Site Quantification of Human Urinary Albumin by a Fluorescence Immunoassay
Clin. Chem., June 1, 2004; 50(6): 1052 - 1055.
[Full Text] [PDF]


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