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Clinical Chemistry 46: 1868-1869, 2000;
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(Clinical Chemistry. 2000;46:1868-1869.)
© 2000 American Association for Clinical Chemistry, Inc.

Articles

Transient Hyperphosphatasemia of Infancy and Childhood: Study of 194 Cases

Darina Behúlová1,a, Vladimír Bzdúch2, Darina Holesová1, Alena Vasilenková1 and Jozef Ponec1

1 Department of Clinical Biochemistry, and,
2 1st Pediatric Clinics, University Children’s Hospital, Limbová 1 , 833 40 Bratislava, Slovakia
a Author for correspondence. Fax 421-7-54-788361.


   To the Editor:
 
Transient hyperphosphatasemia of infancy and childhood (TH) is a temporary and isolated increase of serum alkaline phosphatase (ALP; EC 3.1.3.1) activity occurring without obvious cause during the first years of life. Despite several reports about this phenomenon, the origin of TH remains obscure.

Over a period of 8 years (1992–1999), we detected 194 cases of TH in 106 boys and 88 girls. The hyperphosphatasemia was discovered fortuitously during routine investigations in outpatient and inpatient departments of a children’s hospital with a capacity of 500 beds. A wide variety of clinical disorders was associated with this condition (gastrointestinal diseases, 24%; respiratory infections, 21%; congenital anomalies and inborn . . . [Full Text of this Article]


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