Clinical Chemistry
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Clinical Chemistry 46: 871-872, 2000;
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(Clinical Chemistry. 2000;46:871-872.)
© 2000 American Association for Clinical Chemistry, Inc.

Technical Briefs

Latex-enhanced Immunoturbidimetry Allows D-Dimer Determination in Plasma and Serum Samples

Wolfgang Kortea and Walter Riesen1

1 Institute for Clinical Chemistry and Hematology, Kantonsspital, 9007 St. Gallen, Switzerland
a author for correspondence: fax 41-71-494-3900, e-mail Wolfgang.Korte@gd-ikch.sg.ch

Quantitative D-dimer determination has become routine practice in patients evaluated for the presence of deep venous thrombosis or pulmonary emboli (1)(2)(3). D-Dimer concentrations below a certain cutoff specifically defined for each assay [500 µg/L for ELISA and comparable assays (3)] are considered sufficient evidence to exclude a deep venous thrombosis or pulmonary emboli if the pretest probability is low (4). In addition, D-dimer has been shown to be a reliable indicator of coagulation activation in disseminated intravascular coagulation (5) and malignancy (6). More recently, the relevance of the determination of D-dimer in arterial disease was evaluated (7), and it was shown that D-dimer is a very good predictor of recurrent acute coronary syndromes after a first event (8). There is also some indication that the amount of D-dimer generated correlates to some extent with the degree of atherosclerosis (9).

Fully quantitative D-dimer assays and their automation are recent . . . [Full Text of this Article]


Acknowledgments


References




eLetters:

Read all eLetters

D-Dimer in Citrated Plasma and Serum
Manfred Lammers
Clinical Chemistry Online, 15 Jun 2000 [Full text]
D-dimer in plasma and serum
Wolfgang Korte
Clinical Chemistry Online, 20 Jun 2000 [Full text]

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