Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 46: 887-888, 2000;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rosenberg Zand, R. S.
Right arrow Articles by Diamandis, E. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rosenberg Zand, R. S.
Right arrow Articles by Diamandis, E. P.
Related Collections
Right arrow Endocrinology and Metabolism
(Clinical Chemistry. 2000;46:887-888.)
© 2000 American Association for Clinical Chemistry, Inc.

Letters

Genistein: A Potent Natural Antiandrogen

Rachel S. Rosenberg Zand1,3, David J.A. Jenkins1 and Eleftherios P. Diamandis3,2,a

Departments of,
1 Nutritional Sciences, and,
2 Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 3E2
3 Department of Pathology, and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
a Address correspondence to this author at: Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario, Canada M5G 1X5. Fax 416-586-8628; e-mail ediamandis@mtsinai.on.ca.


To the Editor:

Flavonoids and other polyphenolic natural compounds have attracted much attention as candidate cancer preventive and anticarcinogenic agents, as well as antiatherogenic and antioxidant compounds (1). Although the public now consumes these compounds in substantial amounts from dietary sources, food supplements, and more recently, as "nutraceutical" tablets, their actual mode of action is not fully defined. The most compelling hypotheses correlate the biological action of flavonoids to their ability to mimic natural estrogens (2)(3) such as estradiol, or to act as antioxidants (4). Indeed, genistein, a natural soy isoflavone, is among the most potent known phytoestrogens. The ability of flavonoids to act as androgen mimics or antiandrogens . . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


Home page
 Cancer Prevention ResearchHome page
N. E. Gray, X. Liu, R. Choi, M. R. Blackman, and J. T. Arnold
Endocrine-Immune-Paracrine Interactions in Prostate Cells as Targeted by Phytomedicines
Cancer Prevention Research, February 1, 2009; 2(2): 134 - 142.
[Abstract] [Full Text] [PDF]

eLetters:

Read all eLetters

Genistein: a potent natural antiandrogen or an effective apoptotic trigger?
Ferdinando Mannello
Clinical Chemistry Online, 7 Nov 2000 [Full text]

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American Association for Clinical Chemistry.