| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Technical Briefs |
Departments of
1
Pediatrics and
2
Obstetrics and Gynecology, Giannina Gaslini Children’s University Hospital, I-16147 Genoa, Italy
3
Institute of Anatomy, Catholic University, Largo Francesco Vito, 1 I-00168 Rome, Italy
aauthor for correspondence: fax 39-630154813, e-mail fabrizio.michetti@rm.unicatt.it
Intraventricular hemorrhage (IVH) is the most common form of
cerebral hemorrhage in preterm infants, affecting 
15–20%
(1). Despite accurate postnatal monitoring, IVH is difficult
to diagnose during the first 72 h after birth because at this
stage, clinical symptoms and radiologic assessment of brain damage may
still be silent (2). The availability in these patients of
quantitative indicators suggesting subclinical lesions at a
time when the monitoring indicators are unable to detect bleeding is
therefore important. Furthermore, quantification of the extent of the
hemorrhaged lesion could permit the prevention and/or treatment of
clinical neurologic damage.
S100B is an acidic calcium-binding protein found in the nervous system, where it is concentrated in glial cells (3). The presence of increased S100B in the blood and cerebrospinal fluid (CSF) is a consolidated marker of brain damage in adults and children (4)(5)(6)(7)(8) and has been proposed recently for use in preterm newborns developing IVH (9). We have detected the S100B protein in the urine of preterm newborns under normal conditions and established reference values for the protein at the first urination (10). The present work, extending from the earlier study, investigates urine S100B in preterm newborns developing IVH to offer an indicator for the early detection of IVH.
We performed a case-control study on 18 preterm newborns (29–35 weeks
of gestation) with IVH in whom urine S100B was measured at first
urination (time 0) and at 24 (time 1), 48 (time 2), and 72 h of
age (time 3). IVH was diagnosed at 72 h after birth by ultrasound
scanning (11): eight infants were classified as grade II
(IVH without ventricular dilatation); eight as grade III (IVH with
ventricular dilatation); and two
Acknowledgments
References
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  A Pickering, J Carter, I Hanning, and W Townend Emergency department measurement of urinary S100B in children following head injury: can extracranial injury confound findings? Emerg. Med. J., February 1, 2008; 25(2): 88 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gazzolo, E. Marinoni, R. Di Iorio, M. Lituania, M. Marras, M. Bruschettini, P. Bruschettini, R. Frulio, F. Michetti, F. Petraglia, et al. High Maternal Blood S100B Concentrations in Pregnancies Complicated by Intrauterine Growth Restriction and Intraventricular Hemorrhage Clin. Chem., May 1, 2006; 52(5): 819 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gazzolo, E. Marinoni, R. Di Iorio, M. Bruschettini, M. Kornacka, M. Lituania, U. Majewska, G. Serra, and F. Michetti Measurement of Urinary S100B Protein Concentrations for the Early Identification of Brain Damage in Asphyxiated Full-term Infants Arch Pediatr Adolesc Med, December 1, 2003; 157(12): 1163 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Michetti and D. Gazzolo S100B Protein in Biological Fluids: A Tool for Perinatal Medicine Clin. Chem., December 1, 2002; 48(12): 2097 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gazzolo, M. Bruschettini, R. Di Iorio, E. Marinoni, M. Lituania, M. Marras, R. Sarli, P. L. Bruschettini, and F. Michetti Maternal Nitric Oxide Supplementation Decreases Cord Blood S100B in Intrauterine Growth-retarded Fetuses Clin. Chem., April 1, 2002; 48(4): 647 - 650. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
