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Clinical Chemistry 47: 2067, 2001;
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(Clinical Chemistry. 2001;47:2067.)
© 2001 American Association for Clinical Chemistry, Inc.

Letters

Functional Sensitivity and Recovery of Thyroid-stimulating Hormone

Alun Price1a, Christine Burgin1, Ian Catch1 and Martin Cruise1

1 Department of Clinical Chemistry, Northern General Hospital NHS Trust, Herries Road, Sheffield S57AU, United Kingdom

aAuthor for correspondence. Fax 0114-271-5313; e-mail alun.price@bigfoot.com.


To the Editor:

Comparisons of the Vitros ECi thyroid-stimulating hormone (TSH) method with the AxSym (1), Immulite (1)(2), Elecsys (2), and ADVIA Centaur (2) have shown an unexplained progressive negative bias <0.2 mIU/L, a phenomenon that we have also observed (Fig. 1A ). To investigate the bias, we diluted the TSH International Reference Preparation 80/558 (predominately pituitary TSH) and serum from a patient with untreated hypothyroidism (a mixture of pituitary and hepatic sialylated TSH) in serum pooled from patients receiving suppressive doses of thyroxine for thyroid cancer and with undetectable TSH values by the ADVIA ACS:180, Vitros ECi TSH, and Roche Elecsys methods. To obtain accurate . . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
S. Donadio, A. Pascual, J. H.H. Thijssen, and C. Ronin
Feasibility Study of New Calibrators for Thyroid-Stimulating Hormone (TSH) Immunoprocedures Based on Remodeling of Recombinant TSH to Mimic Glycoforms Circulating in Patients with Thyroid Disorders
Clin. Chem., February 1, 2006; 52(2): 286 - 297.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
M. L. Rawlins and W. L. Roberts
Performance Characteristics of Six Third-Generation Assays for Thyroid-Stimulating Hormone
Clin. Chem., December 1, 2004; 50(12): 2338 - 2344.
[Abstract] [Full Text] [PDF]


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