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Clinical Chemistry 47: 2148-2150, 2001;
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(Clinical Chemistry. 2001;47:2148-2150.)
© 2001 American Association for Clinical Chemistry, Inc.

Articles

Supraregional Interlaboratory Quality-Control Survey for an Immunoradiometric Renin Assay

Adriano Piffanelli1a, Alberto Morganti2, Franco Mantero3, Antonio Cianetti4, Gian Carlo Zucchelli5, Gloria Giovannini1 and Dario Pelizzola1

1 Department of Experimental and Clinical Medicine, Section of Nuclear Medicine University, 44100 Ferrara, Italy;
2 Hypertension and Clinical Physiology Center, Institute of Clinical Medicine University, 20100 Milan, Italy;
3 Endocrinology Section University, 60100 Ancona, Italy;
4 Central Laboratory RIA Section, S. Camillo Hospital, 00100 Rome, Italy;
5 Institute of Clinical Physiology, National Center of Research, 56100 Pisa, Italy

aaddress correspondence to this author at: Department of Experimental and Clinical Medicine, Section of Nuclear Medicine, Via Luigi Borsari, 46, 44100 Ferrara, Italy; fax 39-0532-236589, e-mail pif@unife.it


   Introduction
 
For the last 20 years, the most widely used method for assessment of the renin-angiotensin system has been the plasma renin activity assay (1). Although the assay gives useful information on the enzymatic function of the renin molecule, the intrinsic characteristics of this method limit its analytical accuracy (2). Immunoradiometric assays for renin, developed in 1985, overcame this limitation of the enzymatic assay because the well-defined monoclonal antibodies provided the means for direct quantification of specific active forms of the enzyme molecule (3)(4). Nevertheless, a critical debate has developed over the use of these assays (5)(6)(7)(8)(9)(10).

A pilot study (11)(12) in a limited number of laboratories (eight Italian centers) found satisfactory indexes of precision for a direct immunoradiometric renin assay (Eria Diagnostics, Sanofi-Pasteur). In our previous experience, the inter- and intralaboratory reproducibility indices of this commercial immunoradiometric assay appeared to be better than those that had been achieved with an enzymatic assay (REN-CTK; Sorin Biomedica), with the differences probably being attributable to the greater complexity of the procedure for the latter assay (11).

Various reports have been published during the past 30 years describing useful . . . [Full Text of this Article]


   Acknowledgments
 

   References
 



The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
D. J. Campbell, J. Nussberger, M. Stowasser, A.H. J. Danser, A. Morganti, E. Frandsen, and J. Menard
Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement
Clin. Chem., May 1, 2009; 55(5): 867 - 877.
[Abstract] [Full Text] [PDF]


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